Literature DB >> 9844729

Vitamin B6 deficiency affects antioxidant defences in rat liver and heart.

L Cabrini1, R Bergami, D Fiorentini, M Marchetti, L Landi, B Tolomelli.   

Abstract

We have evaluated the effects of a diet containing normal amounts of lipids and a marginal content of vitamin B6 on lipid peroxidation. Pyridoxal phosphate concentrations of plasma and liver indicated that an initial deficiency state was reached. Vitamin B6 deficiency led to peroxidative stress: TBARS production was higher in the liver (+18.6%) and even more in the heart (+61%) of deficient rats as compared with controls. Furthermore, significant stimulation of glutathione-dependent enzymes occurred in both heart and liver of deficient rats: glutathione peroxidase activity increased in heart (+144%) and liver (+505%); glutathione reductase increased in heart (+54.9%) and liver (+15.5%). No difference in the total glutathione content of the organs of the two groups was observed. The reduced glutathione/oxidized glutathione ratio was significantly lower in deficient rats. Although the activity of glutathione-dependent enzymes was significantly greater in deficient rats than in controls, this stimulation was only partially able to counteract the peroxidative damage due to vitamin B6 deficiency.

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Year:  1998        PMID: 9844729     DOI: 10.1080/15216549800204222

Source DB:  PubMed          Journal:  Biochem Mol Biol Int        ISSN: 1039-9712


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