BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved. OBJECTIVE: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress. DESIGN: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and an oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y). RESULTS: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively). CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population.
BACKGROUND: Low vitamin B-6 status has been linked to an increased risk of cardiovascular diseases. The cardioprotective effects of vitamin B-6 independent of homocysteine suggest that additional mechanisms may be involved. OBJECTIVE: Our objective was to examine the cross-sectional association of vitamin B-6 status with markers of inflammation and oxidative stress. DESIGN: We measured plasma pyridoxal-5'-phosphate (PLP), C-reactive protein (CRP), and an oxidative DNA damage marker, urinary 8-hydroxydeoxyguanosine (8-OHdG), in Puerto Rican adults who were living in Massachusetts (n = 1205, aged 45-75 y). RESULTS: There was a strong dose-response relation of plasma PLP concentration with plasma CRP. Increasing quartiles of PLP were significantly associated with lower CRP concentrations (geometric means: 4.7, 3.6, 3.1, and 2.5 mg/L; P for trend < 0.0001) and with lower urinary 8-OHdG concentrations (geometric means: 124, 124, 117, and 108 ng/mg creatinine; P for trend: 0.025) after multivariate adjustment. These negative associations persisted after plasma homocysteine was controlled for. Plasma PLP concentrations were significantly correlated with plasma fasting glucose (r = -0.1, P = 0.0006), glycated hemoglobin (r = -0.08, P = 0.006), and homeostasis model assessment of beta cell function (r = 0.082, P = 0.005). Metabolic syndrome, obesity, and diabetes were also significantly associated with low plasma PLP concentrations (P = 0.011, 0.0007, and 0.004, respectively). CONCLUSIONS: Low vitamin B-6 concentrations are associated with inflammation, higher oxidative stress, and metabolic conditions in older Puerto Rican adults. Our data suggest that vitamin B-6 may influence cardiovascular disease risk through mechanisms other than homocysteine and support the notion that nutritional status may influence the health disparities present in this population.
Authors: Aaron R Folsom; Moïse Desvarieux; F Javier Nieto; Lori L Boland; Christie M Ballantyne; Lloyd E Chambless Journal: Atherosclerosis Date: 2003-07 Impact factor: 5.162
Authors: Chao-Qiang Lai; Laurence D Parnell; Aron M Troen; Jian Shen; Heather Caouette; Daruneewan Warodomwichit; Yu-Chi Lee; Jimmy W Crott; Wei Qiao Qiu; Irwin H Rosenberg; Katherine L Tucker; José M Ordovás Journal: Am J Clin Nutr Date: 2010-03-24 Impact factor: 7.045
Authors: Oana M Deac; James L Mills; Clair M Gardiner; Barry Shane; Louise Quinn; Øivind Midttun; Adrian McCann; Klaus Meyer; Per M Ueland; Ruzong Fan; Zhaohui Lu; Lawrence C Brody; Anne M Molloy Journal: J Nutr Date: 2016-08-03 Impact factor: 4.798
Authors: Cornelia M Ulrich; Mary Playdon; Rama Kiblawi; Andreana N Holowatyj; Biljana Gigic; Stefanie Brezina; Anne J M R Geijsen; Jennifer Ose; Tengda Lin; Sheetal Hardikar; Caroline Himbert; Christy A Warby; Jürgen Böhm; Martijn J L Bours; Fränzel J B van Duijnhoven; Tanja Gumpenberger; Dieuwertje E Kok; Janna L Koole; Eline H van Roekel; Petra Schrotz-King; Arve Ulvik; Andrea Gsur; Nina Habermann; Matty P Weijenberg; Per Magne Ueland; Martin Schneider; Alexis Ulrich Journal: Br J Nutr Date: 2020-02-05 Impact factor: 3.718
Authors: Stefanie Zschäbitz; Ting-Yuan David Cheng; Marian L Neuhouser; Yingye Zheng; Roberta M Ray; Joshua W Miller; Xiaoling Song; David R Maneval; Shirley A A Beresford; Dorothy Lane; James M Shikany; Cornelia M Ulrich Journal: Am J Clin Nutr Date: 2012-12-19 Impact factor: 7.045