Literature DB >> 9844579

3-Cyano-4,6-disubstituted-2(1H)-imino or oxopyridines: new antineoplastic agents with high selectivity towards leukemia cell lines.

A H Abadi1, H A al-Khamees.   

Abstract

Two series of 3-cyano-2(1H)-oxopyridine and 3-cyano-2(1H)-iminopyridine derivatives carrying various aryl substituents at position 4 and (4-((7-chloro or trifluoromethylquinol-4-yl)amino)phenyl) substituent at position 6 were synthesized and evaluated for their antitumor activity. Compounds 3f and 6d showed high selectivity towards leukemia cell lines with full panel median growth inhibition GI50 average sensitivity towards all cell lines (MG-MID) at 7.9 and 19.7 microM and leukemia subpanel GI50 average sensitivity towards leukemia cell lines (MG-MID) at 1.74 and 2.9 microM, respectively, also they exhibited full panel total growth inhibition TGI (MG-MID) at 34.8 and 59.0 microM and leukemia subpanel TGI (MG-MID) at 5.3 and 13.5 microM, respectively.

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Year:  1998        PMID： 9844579     DOI： 10.1002/(sici)1521-4184(199810)331:10<319::aid-ardp319>3.3.co;2-m

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  4 in total

1.  CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents.

Authors:  Ismail Salama; Mohamed A O Abdel-Fattah; Marwa S Hany; Shaimaa A El-Sharif; Mahmoud A M El-Naggar; Rasha M H Rashied; Gary A Piazza; Ashraf H Abadi
Journal:  Med Chem       Date:  2012-05       Impact factor: 2.745

2.  Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents.

Authors:  Mohamed A O Abdel-Fattah; Mahmoud A M El-Naggar; Rasha M H Rashied; Bernard D Gary; Gary A Piazza; Ashraf H Abadi
Journal:  Med Chem       Date:  2012-05       Impact factor: 2.745

3.  Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.

Authors:  Ashraf Hassan Abadi; Marwa Saeed Hany; Shimaa Awadain Elsharif; Amal Abdel Haleem Eissa; Bernard Dewayne Gary; Heather Nicole Tinsley; Gary Anthony Piazza
Journal:  Chem Pharm Bull (Tokyo)       Date:  2013       Impact factor: 1.645

4.  Crystal structure of 1-benzyl-4-(2,4-di-chloro-phenyl)-2-imino-1,2,5,6,7,8,9,10-octa-hydro-cyclo-octa-[b]pyridine-3-carbo-nitrile.

Authors:  R A Nagalakshmi; J Suresh; S Maharani; R Ranjith Kumar; P L Nilantha Lakshman
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-10-31
  4 in total

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