Taking advantage of our in-house experimental data on 3-cyano-2-imino-1, 2-dihydropyridine and 3-cyano-2- oxo-1,2-dihydropyridine derivatives as inhibitors of the growth of the human HT-29 colon adenocarcinoma tumor cell line, we have established a highly significant CoMFA and CoMSIA models (q2cv=0.70/0.639). The models were investigated to assure their stability and predictivity (r2pred=0.65/0.61) and successfully applied to design two new potential cell growth inhibitory agents with IC50s in the submicromolar range.
Taking advantage of our in-house experimental data on 3-cyano-2-imino-1, 2-dihydropyridine and n class="Chemical">3-cyano-2- oxo-1,2-dihydropyridine derivatives as inhibitors of the growth of the humanHT-29 colon adenocarcinoma tumor cell line, we have established a highly significant CoMFA and CoMSIA models (q2cv=0.70/0.639). The models were investigated to assure their stability and predictivity (r2pred=0.65/0.61) and successfully applied to design two new potential cell growth inhibitory agents with IC50s in the submicromolar range.
Authors: Eunyi Moon; Richard Lee; Richard Near; Lewis Weintraub; Sharon Wolda; Adam Lerner Journal: Clin Cancer Res Date: 2002-02 Impact factor: 12.531
Authors: Ashraf H Abadi; Dalal A Abouel-Ella; Jochen Lehmann; Heather N Tinsley; Bernard D Gary; Gary A Piazza; Mohammed A O Abdel-Fattah Journal: Eur J Med Chem Date: 2009-09-20 Impact factor: 6.514
Authors: Ashraf H Abadi; Tamer M Ibrahim; Khaled M Abouzid; Jochen Lehmann; Heather N Tinsley; Bernard D Gary; Gary A Piazza Journal: Bioorg Med Chem Date: 2009-07-03 Impact factor: 3.641