| Literature DB >> 9841820 |
G De Serres1, T L Cromeans, B Levesque, N Brassard, C Barthe, M Dionne, H Prud'homme, D Paradis, C N Shapiro, O V Nainan, H S Margolis.
Abstract
An outbreak of hepatitis A in a rural river-island community was found to be associated with consumption of contaminated well water. Specimens from case-patients, the implicated well, and a cesspool suspected to be the source of contamination were all positive for hepatitis A virus (HAV) RNA by immunocapture reverse-transcription polymerase chain reaction. All isolates were identical over about 400 bases from two capsid-encoding regions of the genome, identifying the chain of transmission. Other wells up to 60 m from the cesspool also contained HAV RNA. In addition, HAV RNA was detected in the contamination source well 6 months after the initial contamination, when fecal coliform bacteria were no longer present. These findings demonstrate the utility of viral detection techniques to evaluate contaminated ground water.Entities:
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Year: 1999 PMID： 9841820 DOI： 10.1086/314565
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226