C C Lin1, J Santolaya-Forgas. 1. Department of Obstetrics and Gynecology, University of Chicago, Illinois 60637, USA.
Abstract
OBJECTIVE: To update basic concepts and management strategies of fetal growth restriction (FGR). DATA SOURCE: An English literature search was conducted for pertinent articles related to FGR from 1976 to 1997. Original research articles, review articles, and book chapters were reviewed. METHODS OF STUDY SELECTION: This study was divided into two parts. For this article, both human data and animal data pertinent to understanding causative factors, pathogenesis, clinical type, and pathophysiology were included. To perform a meaningful comparison, the concept of investigators and their methods of investigation were critically compared between the two study periods: 1976-1985 and 1986-1997. TABULATION, INTEGRATION, AND RESULTS: Older concepts involving basic principles of FGR based on animal models during the first study period were integrated with new research findings obtained from human FGR during the second study period. By comparative analysis of older animal data and new human data, current concepts of FGR were synthesized. CONCLUSION: Fetal growth restriction affects a heterogenous group of infants. Despite development of new technology for investigation, many older basic concepts related to FGR are still fundamentally sound. However, new investigations directly performed on human fetuses are a useful expansion of the older concepts.
OBJECTIVE: To update basic concepts and management strategies of fetal growth restriction (FGR). DATA SOURCE: An English literature search was conducted for pertinent articles related to FGR from 1976 to 1997. Original research articles, review articles, and book chapters were reviewed. METHODS OF STUDY SELECTION: This study was divided into two parts. For this article, both human data and animal data pertinent to understanding causative factors, pathogenesis, clinical type, and pathophysiology were included. To perform a meaningful comparison, the concept of investigators and their methods of investigation were critically compared between the two study periods: 1976-1985 and 1986-1997. TABULATION, INTEGRATION, AND RESULTS: Older concepts involving basic principles of FGR based on animal models during the first study period were integrated with new research findings obtained from human FGR during the second study period. By comparative analysis of older animal data and new human data, current concepts of FGR were synthesized. CONCLUSION: Fetal growth restriction affects a heterogenous group of infants. Despite development of new technology for investigation, many older basic concepts related to FGR are still fundamentally sound. However, new investigations directly performed on human fetuses are a useful expansion of the older concepts.
Authors: Sassan HajMohammadi; Keiichi Enjyoji; Marc Princivalle; Patricia Christi; Miroslav Lech; David Beeler; Helen Rayburn; John J Schwartz; Samad Barzegar; Ariane I de Agostini; Mark J Post; Robert D Rosenberg; Nicholas W Shworak Journal: J Clin Invest Date: 2003-04 Impact factor: 14.808
Authors: Nicholas W Shworak; Sassan HajMohammadi; Ariane I de Agostini; Robert D Rosenberg Journal: Glycoconj J Date: 2002 May-Jun Impact factor: 2.916
Authors: Soyhan Bagci; Erwin Brosens; Dick Tibboel; Annelies De Klein; Hanneke Ijsselstijn; Charlotte H W Wijers; Nel Roeleveld; Ivo de Blaauw; Paul M Broens; Iris A L M van Rooij; Alice Hölscher; Thomas M Boemers; Marcus Pauly; Oliver J Münsterer; Eberhard Schmiedeke; Mattias Schäfer; Benno E Ure; Martin Lacher; Vera Choinitzki; Johannes Schumacher; Nadine Zwink; Ekkehart Jenetzky; David Katzer; Joerg Arand; Peter Bartmann; Heiko M Reutter Journal: Eur J Pediatr Date: 2016-03-16 Impact factor: 3.183