Literature DB >> 9838656

Enteric absorption of FK 506: estimation by a block liver perfusion technique in rats.

Y Watanabe1, M Sato, Y Abe, T Yamamoto, Y Kashu, A Horiuchi, Y Hamada, T Nakata, T Lee, K Kawachi.   

Abstract

This perfusion model enables a pharmacokinetic study of enteral absorption and hepatic metabolic rate simultaneously. FK 506 is absorbed mainly via the proximal small intestine and metabolized rapidly by the liver during single passage. These results may lead to further analyses of absorption and metabolism of FK 506 under various conditions.

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Year:  1998        PMID： 9838656     DOI： 10.1016/s0041-1345(98)01233-0

Source DB:  PubMed          Journal:  Transplant Proc        ISSN： 0041-1345            Impact factor:   1.066


  2 in total

1.  Pharmacokinetics of mycophenolic acid, tacrolimus and sirolimus after gastric bypass surgery in end-stage renal disease and transplant patients: a pilot study.

Authors:  Christin C Rogers; Rita R Alloway; J Wesley Alexander; Michael Cardi; Jennifer Trofe; Alexander A Vinks
Journal:  Clin Transplant       Date:  2008 May-Jun       Impact factor: 2.863

2.  The tacrolimus metabolism rate influences renal function after kidney transplantation.

Authors:  Gerold Thölking; Christian Fortmann; Raphael Koch; Hans Ulrich Gerth; Dirk Pabst; Hermann Pavenstädt; Iyad Kabar; Anna Hüsing; Heiner Wolters; Stefan Reuter; Barbara Suwelack
Journal:  PLoS One       Date:  2014-10-23       Impact factor: 3.240
  2 in total

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