| Literature DB >> 9834146 |
T S Kam1, K M Sim, T Koyano, M Toyoshima, M Hayashi, K Komiyama.
Abstract
The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3alpha-amino-14beta-hydroxypregnan-20-one (7), and 15alpha-hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.Entities:
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Year: 1998 PMID： 9834146 DOI： 10.1021/np970545f
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050