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Literature DB >> 9831530

Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.

Abstract

Aminoglycoside antibiotics inhibit protein biosynthesis and various ribozymes. Structural electrostatic complementarity can explain the inhibition mechanism of the hammerhead ribozyme: positively charged ammonium groups match the negatively charged metal-ion-binding pockets created by the RNA fold's electrostatic field.

Entities: Chemical

Mesh：

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Year: 1998 PMID： 9831530 DOI： 10.1016/s1074-5521(98)90286-1

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

32 in total

Review 1. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

Authors: L P Kotra; J Haddad; S Mobashery
Journal: Antimicrob Agents Chemother Date: 2000-12 Impact factor: 5.191

2. Inhibition of RNase P RNA cleavage by aminoglycosides.

Authors: N E Mikkelsen; M Brännvall; A Virtanen; L A Kirsebom
Journal: Proc Natl Acad Sci U S A Date: 1999-05-25 Impact factor: 11.205

3. Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding.

Authors: Kenneth F Blount; Yitzhak Tor
Journal: Nucleic Acids Res Date: 2003-10-01 Impact factor: 16.971

4. A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

Authors: Indrajit Das; Jérôme Désiré; Dinesh Manvar; Isabelle Baussanne; Virendra N Pandey; Jean-Luc Décout
Journal: J Med Chem Date: 2012-06-22 Impact factor: 7.446

10. Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.

Authors: Olga Aminova; Dustin J Paul; Jessica L Childs-Disney; Matthew D Disney
Journal: Biochemistry Date: 2008-12-02 Impact factor: 3.162

Deciphering RNA recognition: aminoglycoside binding to the hammerhead ribozyme.

Review 1. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance.

2. Inhibition of RNase P RNA cleavage by aminoglycosides.

3. Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding.

4. A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

5. Evidence that electrostatic interactions dictate the ligand-induced arrest of RNA global flexibility.

6. Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction.

7. Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation.

8. Enzymatic incorporation and utilization of an emissive 6-azauridine.

9. Molecular recognition of 6'-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches.

10. Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.