OBJECTIVE: This study aimed to examine predictive factors and treatment outcome and to devise a staging method for malignant lateral skull base disease. STUDY DESIGN: The study design was a retrospective review of all lateral skull base surgery cases. SETTING: The study was conducted at a tertiary referral center. PATIENTS: Of 317 lateral skull base lesions, 81 patients were found to have malignant disease. Three groups were identified, and the data were analyzed according to the following: epithelial malignancies, 30 patients; malignancies of salivary gland origin, 23 patients; and malignancies of mesenchymal origin, 28 patients. The mean age was 48.5 years with a range of 5-83 years. There were 42 males and 39 females. Our mean follow-up time was 54 months with a range of 1-180 months. Forty-three patients were alive without evidence of recurrent disease, 6 were living with disease, 25 were dead of disease, 3 died of other causes, and 4 were lost to follow-up. INTERVENTIONS: All patients underwent surgery with curative intent. Forty-two received adjuvant radiation, and 8 received chemotherapy. MAIN OUTCOME MEASURES: Treatment failure, survival, cranial nerve deficits, complications, and predictive factors were analyzed. RESULTS: A 58% treatment success rate was observed. Epithelial and salivary malignancy had a poorer prognosis, and pain and facial nerve dysfunction at presentation carried a worse prognosis. CONCLUSIONS: Lateral skull base malignancy is a rare entity that continues to challenge cranial base surgeons. Cranial nerve deficits and complications are frequent. The success rate of treatment is dependent on histology and disease extent.
OBJECTIVE: This study aimed to examine predictive factors and treatment outcome and to devise a staging method for malignant lateral skull base disease. STUDY DESIGN: The study design was a retrospective review of all lateral skull base surgery cases. SETTING: The study was conducted at a tertiary referral center. PATIENTS: Of 317 lateral skull base lesions, 81 patients were found to have malignant disease. Three groups were identified, and the data were analyzed according to the following: epithelial malignancies, 30 patients; malignancies of salivary gland origin, 23 patients; and malignancies of mesenchymal origin, 28 patients. The mean age was 48.5 years with a range of 5-83 years. There were 42 males and 39 females. Our mean follow-up time was 54 months with a range of 1-180 months. Forty-three patients were alive without evidence of recurrent disease, 6 were living with disease, 25 were dead of disease, 3 died of other causes, and 4 were lost to follow-up. INTERVENTIONS: All patients underwent surgery with curative intent. Forty-two received adjuvant radiation, and 8 received chemotherapy. MAIN OUTCOME MEASURES: Treatment failure, survival, cranial nerve deficits, complications, and predictive factors were analyzed. RESULTS: A 58% treatment success rate was observed. Epithelial and salivary malignancy had a poorer prognosis, and pain and facial nerve dysfunction at presentation carried a worse prognosis. CONCLUSIONS: Lateral skull base malignancy is a rare entity that continues to challenge cranial base surgeons. Cranial nerve deficits and complications are frequent. The success rate of treatment is dependent on histology and disease extent.
Authors: Luc G T Morris; Saral Mehra; Jatin P Shah; Mark H Bilsky; Samuel H Selesnick; Dennis H Kraus Journal: Head Neck Date: 2011-09-23 Impact factor: 3.147
Authors: Nichole R Dean; Hilliary N White; Dale S Carter; Renee A Desmond; William R Carroll; Benjamin M McGrew; Eben L Rosenthal Journal: Laryngoscope Date: 2010-08 Impact factor: 3.325
Authors: Omer J Ungar; Joseph B Nadol; William C Faquin; John P Carey; Ophir Handzel; Felipe Santos Journal: Laryngoscope Date: 2019-08-01 Impact factor: 3.325
Authors: Zoukaa Sargi; Robert Gerring; Simon Angeli; David Arnold; Adrien Eshraghi; Francisco Civantos; Fred Telischi; Donald Weed Journal: Skull Base Date: 2010-05