OBJECTIVES/HYPOTHESIS: To evaluate survival outcomes in patients undergoing temporal bone resection. STUDY DESIGN: Retrospective review. METHODS: From 2002 to 2009 a total of 65 patients underwent temporal bone resection for epithelial (n = 47) and salivary (n = 18) skull base malignancies. Tumor characteristics, defect reconstruction, and postoperative course were assessed. Outcomes measured included disease-free survival and cancer recurrence. RESULTS: The majority of patients presented with recurrent (65%), advanced stage (94%), cutaneous (72%), and squamous cell carcinoma (57%). Thirty-nine patients had perineural invasion (60%) and required facial nerve resection; 16 (25%) had intracranial extension. Local (n = 6), regional (n = 2), or free flap (n = 46) reconstruction was required in 80% of patients. Free flap donor sites included the anterolateral thigh (31%), radial forearm free flap (19%), rectus (35%), and latissimus (4%). The average hospital stay was 4.9 days (range, 1-28 days). The overall complication rate was 15% and included stroke (n = 4), cerebrospinal fluid leak (n = 2), hematoma formation (n = 1), infection (n = 1), flap loss (n = 1), and postoperative myocardial infarction (n = 1). A total of 22 patients (34%) developed cancer recurrence during the follow-up period (median, 10 months), 17 (77%) of whom presented with recurrent disease at the time of temporal bone resection. Two-year disease-free survival was 68%, and 5-year disease-free survival was 50%. CONCLUSIONS: Aggressive surgical resection and reconstruction is recommended for primary and recurrent skull base malignancies with acceptable morbidity and improved disease-free survival.
OBJECTIVES/HYPOTHESIS: To evaluate survival outcomes in patients undergoing temporal bone resection. STUDY DESIGN: Retrospective review. METHODS: From 2002 to 2009 a total of 65 patients underwent temporal bone resection for epithelial (n = 47) and salivary (n = 18) skull base malignancies. Tumor characteristics, defect reconstruction, and postoperative course were assessed. Outcomes measured included disease-free survival and cancer recurrence. RESULTS: The majority of patients presented with recurrent (65%), advanced stage (94%), cutaneous (72%), and squamous cell carcinoma (57%). Thirty-nine patients had perineural invasion (60%) and required facial nerve resection; 16 (25%) had intracranial extension. Local (n = 6), regional (n = 2), or free flap (n = 46) reconstruction was required in 80% of patients. Free flap donor sites included the anterolateral thigh (31%), radial forearm free flap (19%), rectus (35%), and latissimus (4%). The average hospital stay was 4.9 days (range, 1-28 days). The overall complication rate was 15% and included stroke (n = 4), cerebrospinal fluid leak (n = 2), hematoma formation (n = 1), infection (n = 1), flap loss (n = 1), and postoperative myocardial infarction (n = 1). A total of 22 patients (34%) developed cancer recurrence during the follow-up period (median, 10 months), 17 (77%) of whom presented with recurrent disease at the time of temporal bone resection. Two-year disease-free survival was 68%, and 5-year disease-free survival was 50%. CONCLUSIONS: Aggressive surgical resection and reconstruction is recommended for primary and recurrent skull base malignancies with acceptable morbidity and improved disease-free survival.
Authors: Marc D Moncrieff; Stuart A Hamilton; George H Lamberty; Charles M Malata; David G Hardy; Robert Macfarlane; David A Moffat Journal: J Plast Reconstr Aesthet Surg Date: 2007-01-31 Impact factor: 2.740
Authors: Eben L Rosenthal; Teresa King; Benjamin M McGrew; William Carroll; J Scott Magnuson; Mark K Wax Journal: Head Neck Date: 2008-05 Impact factor: 3.147
Authors: Luc G T Morris; Saral Mehra; Jatin P Shah; Mark H Bilsky; Samuel H Selesnick; Dennis H Kraus Journal: Head Neck Date: 2011-09-23 Impact factor: 3.147
Authors: Kristen L Seligman; Daniel Q Sun; Patrick P Ten Eyck; Nathan M Schularick; Marlan R Hansen Journal: Laryngoscope Date: 2019-03-15 Impact factor: 3.325
Authors: Amit Walia; Jake J Lee; Ryan S Jackson; Angela C Hardi; Craig A Bollig; Evan M Graboyes; Joseph Zenga; Sidharth V Puram; Patrik Pipkorn Journal: Otolaryngol Head Neck Surg Date: 2021-09-07 Impact factor: 5.591
Authors: Moran Amit; Ayelet Eran; Salem Billan; Eran Fridman; Shorook Na'ara; Tomer Charas; Ziv Gil Journal: J Neurol Surg B Skull Base Date: 2016-02-26