Literature DB >> 9826911

Gene structure and chromosomal localization of the human P2X7 receptor.

G N Buell1, F Talabot, A Gos, J Lorenz, E Lai, M A Morris, S E Antonarakis.   

Abstract

The genomic organization for the human P2X7 receptor gene was determined to comprise 13 exons. Alignment of the exon-intron junctions with those for the rat P2X2 gene demonstrated a precise conservation of the boundaries for the first 10 introns. The human P2X7 receptor gene was localized by in situ hybridization to chromosome 12q24. Radiation hybrid mapping indicated that this is within 130 kb of the gene for the homologous P2X4 receptor.

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Year:  1998        PMID： 9826911

Source DB:  PubMed          Journal:  Receptors Channels        ISSN： 1060-6823


  31 in total

Review 1.  A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases.

Authors:  Nishkantha Arulkumaran; Robert J Unwin; Frederick Wk Tam
Journal:  Expert Opin Investig Drugs       Date:  2011-04-21       Impact factor: 6.206

2.  A truncated P2X7 receptor variant (P2X7-j) endogenously expressed in cervical cancer cells antagonizes the full-length P2X7 receptor through hetero-oligomerization.

Authors:  Ying-Hong Feng; Xin Li; Liqin Wang; Lingying Zhou; George I Gorodeski
Journal:  J Biol Chem       Date:  2006-04-18       Impact factor: 5.157

Review 3.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

Review 4.  The role of P2X7 receptors in tissue fibrosis: a brief review.

Authors:  Daniela Gentile; Mariarita Natale; Pietro Enea Lazzerini; Pier Leopoldo Capecchi; Franco Laghi-Pasini
Journal:  Purinergic Signal       Date:  2015-08-29       Impact factor: 3.765

Review 5.  Nucleotide receptors in the nervous system. An abundant component using diverse transduction mechanisms.

Authors:  E A Barnard; J Simon; T E Webb
Journal:  Mol Neurobiol       Date:  1997-10       Impact factor: 5.590

6.  Regulation of P2X(7) gene transcription.

Authors:  Lingyin Zhou; Liping Luo; Xiaoping Qi; Xin Li; George I Gorodeski
Journal:  Purinergic Signal       Date:  2009-07-16       Impact factor: 3.765

7.  Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function.

Authors:  Chengqun Sun; Jessica Chu; Sarita Singh; Russell D Salter
Journal:  Purinergic Signal       Date:  2009-10-17       Impact factor: 3.765

8.  P2X7 and NRAMP1/SLC11 A1 gene polymorphisms in Mexican mestizo patients with pulmonary tuberculosis.

Authors:  P Niño-Moreno; D Portales-Pérez; B Hernández-Castro; L Portales-Cervantes; V Flores-Meraz; L Baranda; A Gómez-Gómez; V Acuña-Alonzo; J Granados; R González-Amaro
Journal:  Clin Exp Immunol       Date:  2007-06       Impact factor: 4.330

9.  P2X(7) receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin.

Authors:  Xin Li; Xiaoping Qi; Lingyin Zhou; Wen Fu; Fadi W Abdul-Karim; Gregory Maclennan; George I Gorodeski
Journal:  Purinergic Signal       Date:  2009-04-28       Impact factor: 3.765

10.  MicroRNAs miR-186 and miR-150 down-regulate expression of the pro-apoptotic purinergic P2X7 receptor by activation of instability sites at the 3'-untranslated region of the gene that decrease steady-state levels of the transcript.

Authors:  Lingyin Zhou; Xiaoping Qi; Judith A Potashkin; Fadi W Abdul-Karim; George I Gorodeski
Journal:  J Biol Chem       Date:  2008-08-05       Impact factor: 5.157
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