Literature DB >> 26318434

The role of P2X7 receptors in tissue fibrosis: a brief review.

Daniela Gentile1, Mariarita Natale2, Pietro Enea Lazzerini3, Pier Leopoldo Capecchi4, Franco Laghi-Pasini5.   

Abstract

Many previous studies have demonstrated that P2X(7) receptors (P2X(7)Rs) have a pleiotropic function in different pathological conditions and could represent a novel target for the treatment of a range of diseases. In particular, recent studies have explored the role of P2X(7)R in fibrosis, the pathological outcome of most chronic inflammatory diseases. The aim of this review is to discuss the biological features of P2X(7)R and summarize the current knowledge about the putative role of the P2X(7)R in triggering fibrosis in a wide spectrum of organs such as the lung, kidney, liver, pancreas, and heart.

Entities:  

Keywords:  ATP; Fibrotic diseases; Inflammation; P2X7 receptor

Mesh：

Substances：

Year:  2015        PMID： 26318434      PMCID： PMC4648791          DOI： 10.1007/s11302-015-9466-3

Source DB:  PubMed          Journal:  Purinergic Signal        ISSN： 1573-9538            Impact factor:   3.765


  86 in total

1.  Localisation of P2X5 and P2X7 receptors by immunohistochemistry in rat stratified squamous epithelia.

Authors:  U Gröschel-Stewart; M Bardini; T Robson; G Burnstock
Journal:  Cell Tissue Res       Date:  1999-06       Impact factor: 5.249

Review 2.  Myofibroblasts and mechano-regulation of connective tissue remodelling.

Authors:  James J Tomasek; Giulio Gabbiani; Boris Hinz; Christine Chaponnier; Robert A Brown
Journal:  Nat Rev Mol Cell Biol       Date:  2002-05       Impact factor: 94.444

3.  Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems.

Authors:  S A Deuchars; L Atkinson; R E Brooke; H Musa; C J Milligan; T F Batten; N J Buckley; S H Parson; J Deuchars
Journal:  J Neurosci       Date:  2001-09-15       Impact factor: 6.167

Review 4.  Pathophysiology and therapeutic potential of purinergic signaling.

Authors:  Geoffrey Burnstock
Journal:  Pharmacol Rev       Date:  2006-03       Impact factor: 25.468

Review 5.  Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation.

Authors:  M J L Bours; E L R Swennen; F Di Virgilio; B N Cronstein; P C Dagnelie
Journal:  Pharmacol Ther       Date:  2006-06-19       Impact factor: 12.310

Review 6.  Membrane compartments and purinergic signalling: occurrence and function of P2X receptors in lung.

Authors:  Kathrin Barth; Michael Kasper
Journal:  FEBS J       Date:  2008-12-09       Impact factor: 5.542

Review 7.  Impact of ectoenzymes on p2 and p1 receptor signaling.

Authors:  Filip Kukulski; Sébastien A Lévesque; Jean Sévigny
Journal:  Adv Pharmacol       Date:  2011

Review 8.  Monitoring tissue repair and fibrosis from a distance.

Authors:  K T Weber
Journal:  Circulation       Date:  1997-10-21       Impact factor: 29.690

9.  The purinergic P2×7 receptor is expressed on monocytes in Behçet's disease and is modulated by TNF-α.

Authors:  Monica Castrichini; Pietro Enea Lazzerini; Alessandra Gamberucci; Pier Leopoldo Capecchi; Rossella Franceschini; Mariarita Natale; Mohamed Hammoud; Antonio Moramarco; Stefania Zimbone; Elena Gianchecchi; Cinzia Montilli; Gianluca Ricci; Enrico Selvi; Luca Cantarini; Mauro Galeazzi; Franco Laghi-Pasini
Journal:  Eur J Immunol       Date:  2013-10-24       Impact factor: 5.532

10.  Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release.

Authors:  A Solini; P Chiozzi; A Morelli; R Fellin; F Di Virgilio
Journal:  J Cell Sci       Date:  1999-02       Impact factor: 5.285
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  18 in total

Review 1.  Purinergic Signalling: Therapeutic Developments.

Authors:  Geoffrey Burnstock
Journal:  Front Pharmacol       Date:  2017-09-25       Impact factor: 5.810

2.  P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung.

Authors:  K Barth; R Bläsche; A Neißer; S Bramke; J A Frank; M Kasper
Journal:  Histochem Cell Biol       Date:  2016-09-23       Impact factor: 4.304

3.  Liver kinase B1/AMP-activated protein kinase-mediated regulation by gentiopicroside ameliorates P2X7 receptor-dependent alcoholic hepatosteatosis.

Authors:  Xia Li; Yu Zhang; Quan Jin; Kai-Li Xia; Min Jiang; Ben-Wen Cui; Yan-Ling Wu; Shun-Zong Song; Li-Hua Lian; Ji-Xing Nan
Journal:  Br J Pharmacol       Date:  2018-03-09       Impact factor: 8.739

4.  The P2X7 purinergic receptor in intervertebral disc degeneration.

Authors:  Letizia Penolazzi; Leticia S Bergamin; Elisabetta Lambertini; Valentina V Poma; Alba C Sarti; Pasquale De Bonis; Francesco Di Virgilio; Roberta Piva
Journal:  J Cell Physiol       Date:  2021-10-19       Impact factor: 6.513

5.  P2X7 Receptor and Heart Function in a Mouse Model of Systemic Inflammation Due to High Fat Diet.

Authors:  Francesco Raggi; Chiara Rossi; Francesco Faita; Mariarosaria Distaso; Claudia Kusmic; Anna Solini
Journal:  J Inflamm Res       Date:  2022-04-14

6.  Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells.

Authors:  Mariachiara Zuccarini; Patricia Giuliani; Silvana Buccella; Valentina Di Liberto; Giuseppa Mudò; Natale Belluardo; Marzia Carluccio; Margherita Rossini; Daniele Filippo Condorelli; Michel Piers Rathbone; Francesco Caciagli; Renata Ciccarelli; Patrizia Di Iorio
Journal:  Purinergic Signal       Date:  2017-06-14       Impact factor: 3.765

Review 7.  The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

Authors:  Luiz E B Savio; Paola de Andrade Mello; Cleide Gonçalves da Silva; Robson Coutinho-Silva
Journal:  Front Pharmacol       Date:  2018-02-06       Impact factor: 5.810

8.  Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.

Authors:  Daniela Gentile; Pietro E Lazzerini; Alessandra Gamberucci; Mariarita Natale; Enrico Selvi; Francesca Vanni; Alessandra Alì; Paolo Taddeucci; Silvia Del-Ry; Manuela Cabiati; Veronica Della-Latta; David J Abraham; Maria A Morales; Rosella Fulceri; Franco Laghi-Pasini; Pier L Capecchi
Journal:  Front Pharmacol       Date:  2017-09-13       Impact factor: 5.810

Review 9.  The potential of P2X7 receptors as a therapeutic target, including inflammation and tumour progression.

Authors:  Geoffrey Burnstock; Gillian E Knight
Journal:  Purinergic Signal       Date:  2017-11-21       Impact factor: 3.765

10.  Purinergic signalling in the urinary bladder - When function becomes dysfunction.

Authors:  Christopher H Fry; Karen D McCloskey
Journal:  Auton Neurosci       Date:  2021-07-17       Impact factor: 2.355
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