Literature DB >> 9824637

Tranilast and cisplatin as an experimental combination therapy for scirrhous gastric cancer.

K Murahashi1, M Yashiro, T Inoue, S Nishimura, T Matsuoka, T Sawada, M Sowa, K Hirakawa-Ys Chung.   

Abstract

We examined the effect of Tranilast on the reduction of the administered dose of cisplatin using a scirrhous gastric cancer model. Scirrhous gastric cancer cell line, OCUM-2M, and gastric fibroblasts, NF-10, were used. The IC50 values of CDDP to OCUM-2M cells were decreased by Tranilast in vitro. The combination treatment with Tranilast and CDDP decreased the xenografted tumor size. The combination therapy decreased fibrosis and mitosis, and increased apoptosis. These findings suggest that Tranilast increased the CDDP response on scirrhous gastric cancer. The combination treatment with Tranilast and CDDP may be useful as a new therapy for scirrhous gastric carcinoma.

Entities:  

Mesh：

Substances：

Year:  1998        PMID： 9824637     DOI： 10.3892/ijo.13.6.1235

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  7 in total

Review 1.  Reversal of tumor-induced immunosuppression by TGF-beta inhibitors.

Authors:  Slawomir Wojtowicz-Praga
Journal:  Invest New Drugs       Date:  2003-02       Impact factor: 3.850

2.  Cancer-stromal interactions in scirrhous gastric carcinoma.

Authors:  Masakazu Yashiro; Kosei Hirakawa
Journal:  Cancer Microenviron       Date:  2010-01-26

3.  Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor.

Authors:  Atsushi Shiozaki; Michihiro Kudou; Daisuke Ichikawa; Hitoshi Fujiwara; Hiroki Shimizu; Takeshi Ishimoto; Tomohiro Arita; Toshiyuki Kosuga; Hirotaka Konishi; Shuhei Komatsu; Kazuma Okamoto; Yoshinori Marunaka; Eigo Otsuji
Journal:  J Gastroenterol       Date:  2017-04-07       Impact factor: 7.527

4.  Teucrium polium Extract Enhances the Anti-Angiogenic Effect of Tranilast in a Three-Dimensional Fibrin Matrix Model.

Authors:  Fatemeh Sheikhbahaei; Seyed Noureddin Nematollahi-Mahani; Mozafar Khazaei; Mohammad Rasool Khazaei; Saeed Khazayel
Journal:  Asian Pac J Cancer Prev       Date:  2021-08-01

5.  Tranilast enhances the effect of anticancer agents in osteosarcoma.

Authors:  Takayuki Nakashima; Satoshi Nagano; Takao Setoguchi; Hiromi Sasaki; Yoshinobu Saitoh; Shingo Maeda; Setsuro Komiya; Noboru Taniguchi
Journal:  Oncol Rep       Date:  2019-05-06       Impact factor: 3.906

6.  Synthetic Lethality Screening Identifies FDA-Approved Drugs that Overcome ATP7B-Mediated Tolerance of Tumor Cells to Cisplatin.

Authors:  Marta Mariniello; Raffaella Petruzzelli; Luca G Wanderlingh; Raffaele La Montagna; Annamaria Carissimo; Francesca Pane; Angela Amoresano; Ekaterina Y Ilyechova; Michael M Galagudza; Federico Catalano; Roberta Crispino; Ludmila V Puchkova; Diego L Medina; Roman S Polishchuk
Journal:  Cancers (Basel)       Date:  2020-03-06       Impact factor: 6.639

Review 7.  Crosstalk Between Cancer Associated Fibroblasts and Cancer Cells in Scirrhous Type Gastric Cancer.

Authors:  Yuichiro Miki; Masakazu Yashiro; Lidia Moyano-Galceran; Atsushi Sugimoto; Masaichi Ohira; Kaisa Lehti
Journal:  Front Oncol       Date:  2020-10-16       Impact factor: 6.244
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.