Literature DB >> 9823465

How tumor cells make use of CD44.

P Herrlich1, J Sleeman, D Wainwright, H König, L Sherman, F Hilberg, H Ponta.   

Abstract

A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growthfactor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

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Year:  1998        PMID： 9823465     DOI： 10.3109/15419069809004470

Source DB:  PubMed          Journal:  Cell Adhes Commun        ISSN： 1023-7046


  9 in total

1.  Neutrophil migration across intestinal epithelium: evidence for a role of CD44 in regulating detachment of migrating cells from the luminal surface.

Authors:  Jennifer C Brazil; Winston Y Lee; Keli N Kolegraff; Asma Nusrat; Charles A Parkos; Nancy A Louis
Journal:  J Immunol       Date:  2010-10-25       Impact factor: 5.422

2.  Decreased elastin deposition and high proliferation of fibroblasts from Costello syndrome are related to functional deficiency in the 67-kD elastin-binding protein.

Authors:  A Hinek; A C Smith; E M Cutiongco; J W Callahan; K W Gripp; R Weksberg
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

3.  CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan.

Authors:  Takayuki Abe; Takasuke Fukuhara; Xiauyu Wen; Akinori Ninomiya; Kohji Moriishi; Yoshihiko Maehara; Osamu Takeuchi; Taro Kawai; Shizuo Akira; Yoshiharu Matsuura
Journal:  J Virol       Date:  2012-04-04       Impact factor: 5.103

Review 4.  Changing neighbours, changing behaviour: cell adhesion molecule-mediated signalling during tumour progression.

Authors:  Gerhard Christofori
Journal:  EMBO J       Date:  2003-05-15       Impact factor: 11.598

5.  α3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration.

Authors:  Jennifer C Brazil; Renpeng Liu; Ronen Sumagin; Keli N Kolegraff; Asma Nusrat; Richard D Cummings; Charles A Parkos; Nancy A Louis
Journal:  J Immunol       Date:  2013-09-25       Impact factor: 5.422

6.  Fabrication and biological evaluation of chitosan coated hyaluronic acid-docetaxel conjugate nanoparticles in CD44(+) cancer cells.

Authors:  Nazanin Shabani Ravari; Navid Goodarzi; Farhad Alvandifar; Mohsen Amini; Effat Souri; Mohammad Reza Khoshayand; Zahra Hadavand Mirzaie; Fatemeh Atyabi; Rassoul Dinarvand
Journal:  Daru       Date:  2016-07-29       Impact factor: 3.117

7.  GE11 peptide modified and reduction-responsive hyaluronic acid-based nanoparticles induced higher efficacy of doxorubicin for breast carcinoma therapy.

Authors:  Danrong Hu; Omar Mezghrani; Lei Zhang; Yi Chen; Xue Ke; Tianyuan Ci
Journal:  Int J Nanomedicine       Date:  2016-10-07

8.  Redox-sensitive micelles for targeted intracellular delivery and combination chemotherapy of paclitaxel and all-trans-retinoid acid.

Authors:  Lingfei Han; Lejian Hu; Fulei Liu; Xin Wang; Xiaoxian Huang; Bowen Liu; Feng Feng; Wenyuan Liu; Wei Qu
Journal:  Asian J Pharm Sci       Date:  2018-09-24       Impact factor: 6.598

9.  Dual targeting curcumin loaded alendronate-hyaluronan- octadecanoic acid micelles for improving osteosarcoma therapy.

Authors:  Yanhai Xi; Tingwang Jiang; Yinglan Yu; Jiangmin Yu; Mintao Xue; Ning Xu; Jiankun Wen; Weiheng Wang; Hailong He; Yan Shen; Daquan Chen; Xiaojian Ye; Thomas J Webster
Journal:  Int J Nanomedicine       Date:  2019-08-09
  9 in total

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