Literature DB >> 9818262

Lectins as chaperones in glycoprotein folding.

E S Trombetta1, A Helenius.   

Abstract

N-glycosylation allows newly synthesized glycoproteins to interact with a lectin-based chaperone system in the endoplasmic reticulum. Binding to the lectins calnexin and calreticulin is mediated by monoglucosylated oligosaccharides that are produced transiently by the deglucosylation and reglucosylation of substrate glycoproteins during their maturation process. In mammalian cells, calnexin, calreticulin and associated factors promote the correct folding and oligomerization of many glycoproteins, providing unique quality control and chaperone functions specific for glycoproteins in the endoplasmic reticulum.

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Year:  1998        PMID： 9818262     DOI： 10.1016/s0959-440x(98)80148-6

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  63 in total

1.  Alpha-glucosidase inhibitors reduce dengue virus production by affecting the initial steps of virion morphogenesis in the endoplasmic reticulum.

Authors:  M P Courageot; M P Frenkiel; C D Dos Santos; V Deubel; P Desprès
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Mutational analysis of the N-linked glycosylation sites of the human insulin receptor.

Authors:  T C Elleman; M J Frenkel; P A Hoyne; N M McKern; L Cosgrove; D R Hewish; K M Jachno; J D Bentley; S E Sankovich; C W Ward
Journal:  Biochem J       Date:  2000-05-01       Impact factor: 3.857

3.  Dynamics of fusion pores connecting membranes of different tensions.

Authors:  Y A Chizmadzhev; P I Kuzmin; D A Kumenko; J Zimmerberg; F S Cohen
Journal:  Biophys J       Date:  2000-05       Impact factor: 4.033

Review 4.  Defective folding and rapid degradation of mutant proteins is a common disease mechanism in genetic disorders.

Authors:  N Gregersen; P Bross; M M Jørgensen; T J Corydon; B S Andresen
Journal:  J Inherit Metab Dis       Date:  2000-07       Impact factor: 4.982

5.  GM1 synthase depends on N-glycosylation for enzyme activity and trafficking to the Golgi complex.

Authors:  J A Martina; J L Daniotti; H J Maccioni
Journal:  Neurochem Res       Date:  2000-05       Impact factor: 3.996

Review 6.  The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSA.

Authors:  Neeraj K Surana; Dennis L Kasper
Journal:  Immunol Rev       Date:  2012-01       Impact factor: 12.988

7.  The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.

Authors:  R Gagescu; N Demaurex; R G Parton; W Hunziker; L A Huber; J Gruenberg
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

8.  Synthesis of fluorine substituted oligosaccharide analogues of monoglucosylated glycan chain, a proposed ligand of lectin-chaperone calreticulin and calnexin.

Authors:  Yukishige Ito; Shinya Hagihara; Midori A Arai; Ichiro Matsuo; Maki Takatani
Journal:  Glycoconj J       Date:  2004       Impact factor: 2.916

Review 9.  Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI.

Authors:  Pradman K Qasba; Boopathy Ramakrishnan; Elizabeth Boeggeman
Journal:  AAPS J       Date:  2006-03-24       Impact factor: 4.009

10.  N-linked glycans with similar location in the fusion protein head modulate paramyxovirus fusion.

Authors:  Veronika von Messling; Roberto Cattaneo
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103
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