Literature DB >> 16584127

Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI.

Pradman K Qasba1, Boopathy Ramakrishnan, Elizabeth Boeggeman.   

Abstract

The availability of structural information on glycosyltransferases is beginning to make structure-based reengineering of these enzymes possible. Mutant glycosyltransferases have been generated that can transfer a sugar residue with a chemically reactive unique functional group to a sugar moiety of glycoproteins, glycolipids, and proteoglycans (glycoconjugates). The presence of modified sugar moiety on a glycoprotein makes it possible to link bioactive molecules via modified glycan chains, thereby assisting in the assembly of bionanoparticles that are useful for developing the targeted drug delivery system and contrast agents for magnetic resonance imaging. The reengineered recombinant glycosyltransferases also make it possible to (1) remodel the oligosaccharide chains of glycoprotein drugs, and (2) synthesize oligosaccharides for vaccine development.

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Year:  2006        PMID： 16584127      PMCID： PMC2751439          DOI： 10.1208/aapsj080123

Source DB:  PubMed          Journal:  AAPS J        ISSN： 1550-7416            Impact factor:   4.009


  63 in total

Review 1.  Carbohydrate-lectin interactions in infectious disease.

Authors:  N Sharon
Journal:  Adv Exp Med Biol       Date:  1996       Impact factor: 2.622

Review 2.  Endocytosis.

Authors:  S Mukherjee; R N Ghosh; F R Maxfield
Journal:  Physiol Rev       Date:  1997-07       Impact factor: 37.312

3.  Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes.

Authors:  A B Herr; D M Ornitz; R Sasisekharan; G Venkataraman; G Waksman
Journal:  J Biol Chem       Date:  1997-06-27       Impact factor: 5.157

4.  Crosslinking of mammalian lectin (galectin-1) by complex biantennary saccharides.

Authors:  Y Bourne; B Bolgiano; D I Liao; G Strecker; P Cantau; O Herzberg; T Feizi; C Cambillau
Journal:  Nat Struct Biol       Date:  1994-12

Review 5.  Regulation of growth factor activation by proteoglycans: what is the role of the low affinity receptors?

Authors:  J Schlessinger; I Lax; M Lemmon
Journal:  Cell       Date:  1995-11-03       Impact factor: 41.582

Review 6.  Carbohydrate recognition systems: functional triads in cell-cell interactions.

Authors:  P R Crocker; T Feizi
Journal:  Curr Opin Struct Biol       Date:  1996-10       Impact factor: 6.809

7.  Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.

Authors:  A Yayon; M Klagsbrun; J D Esko; P Leder; D M Ornitz
Journal:  Cell       Date:  1991-02-22       Impact factor: 41.582

8.  Crystal structure of a wheat germ agglutinin/glycophorin-sialoglycopeptide receptor complex. Structural basis for cooperative lectin-cell binding.

Authors:  C S Wright
Journal:  J Biol Chem       Date:  1992-07-15       Impact factor: 5.157

9.  Cell-type specific and ligand specific enhancement of cellular uptake of oligodeoxynucleoside methylphosphonates covalently linked with a neoglycopeptide, YEE(ah-GalNAc)3.

Authors:  J J Hangeland; J T Levis; Y C Lee; P O Ts'o
Journal:  Bioconjug Chem       Date:  1995 Nov-Dec       Impact factor: 4.774

Review 10.  Metastases: the glycan connection.

Authors:  C Couldrey; J E Green
Journal:  Breast Cancer Res       Date:  2000-07-07       Impact factor: 6.466
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  5 in total

Review 1.  Applications of glycosyltransferases in the site-specific conjugation of biomolecules and the development of a targeted drug delivery system and contrast agents for MRI.

Authors:  Boopathy Ramakrishnan; Elizabeth Boeggeman; Pradman K Qasba
Journal:  Expert Opin Drug Deliv       Date:  2008-02       Impact factor: 6.648

2.  Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method.

Authors:  Elizabeth Boeggeman; Boopathy Ramakrishnan; Charlton Kilgore; Nelly Khidekel; Linda C Hsieh-Wilson; John T Simpson; Pradman K Qasba
Journal:  Bioconjug Chem       Date:  2007-03-20       Impact factor: 4.774

Review 3.  Glycoengineering of Antibodies for Modulating Functions.

Authors:  Lai-Xi Wang; Xin Tong; Chao Li; John P Giddens; Tiezheng Li
Journal:  Annu Rev Biochem       Date:  2019-03-27       Impact factor: 23.643

Review 4.  Site-specific linking of biomolecules via glycan residues using glycosyltransferases.

Authors:  Pradman K Qasba; Elizabeth Boeggeman; Boopathy Ramakrishnan
Journal:  Biotechnol Prog       Date:  2008-04-22

Review 5.  The Potential of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer Based on Body Magnetic Field and Organ-on-the-Chip.

Authors:  Ali Alirezaie Alavijeh; Mohammad Barati; Meisam Barati; Hussein Abbasi Dehkordi
Journal:  Adv Pharm Bull       Date:  2019-08-01
  5 in total

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