| Literature DB >> 9817974 |
K Nakajima1, T Ochiai, T Suzuki, H Shimada, H Hayashi, A Yasumoto, A Takeda, E Hishikawa, K Isono.
Abstract
The relationship between preoperative serum carcinoembryonic antigen (CEA), CA 19-9 and alpha-fetoprotein (AFP) levels and their clinicopathological features were evaluated in gastric cancer patients. The positive rates of CEA, CA 19-9 and AFP were 24.8, 27.6 and 12.7%, respectively. Gastric cancer with deeper tumor invasion was significantly more common among patients positive for these tumor markers. Patients with positive CEA or CA 19-9 values had a significantly high risk of lymph node metastases (p = 0.045 and p = 0.002, respectively). Synchronous liver metastases was more commonly found in patients with a positive CA 19-9 value. A significant difference (p < 0.001) in survival rate was found between patients with positive CA 19-9 values and those with negative values. CA 19-9 is useful for the prognosis of gastric cancer patients, whereas CEA, although unsuitable for prognosis, contributes to the prediction of cancer invasion.Entities:
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Year: 1998 PMID： 9817974 DOI： 10.1159/000030038
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283