Literature DB >> 9813779

Finding specific genes that cause autism: a combination of approaches will be needed to maximize power.

S E Folstein1, E Bisson, S L Santangelo, J Piven.   

Abstract

Although autism is clearly inherited, it may be challenging to find the genes involved: The mechanism of inheritance is unknown, families with an autistic child are usually small, parent-child pairs are rare, and a fairly large number of genes may be involved, some or all of which may have a small effect on the phenotype. We discuss several strategies for finding genes, all of which may be used in combination to find the relevant genes.

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Year:  1998        PMID： 9813779     DOI： 10.1023/a:1026008606672

Source DB:  PubMed          Journal:  J Autism Dev Disord        ISSN： 0162-3257


  22 in total

1.  Social language use in parents of autistic individuals.

Authors:  R Landa; J Piven; M M Wzorek; J O Gayle; G A Chase; S E Folstein
Journal:  Psychol Med       Date:  1992-02       Impact factor: 7.723

2.  Combining extremely concordant sibpairs with extremely discordant sibpairs provides a cost effective way to linkage analysis of quantitative trait loci.

Authors:  C Gu; A Todorov; D C Rao
Journal:  Genet Epidemiol       Date:  1996       Impact factor: 2.135

3.  Extreme discordant sib pairs for mapping quantitative trait loci in humans.

Authors:  N Risch; H Zhang
Journal:  Science       Date:  1995-06-16       Impact factor: 47.728

4.  Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.

Authors:  A Pickles; P Bolton; H Macdonald; A Bailey; A Le Couteur; C H Sim; M Rutter
Journal:  Am J Hum Genet       Date:  1995-09       Impact factor: 11.025

Review 5.  Genetic linkage and mental disorders: an update on analytic methodologies.

Authors:  M Baron
Journal:  Biol Psychiatry       Date:  1994-07-01       Impact factor: 13.382

6.  Identification of a complex congenital heart defect susceptibility locus by using DNA pooling and shared segment analysis.

Authors:  V C Sheffield; M E Pierpont; D Nishimura; J S Beck; T L Burns; M A Berg; E M Stone; S R Patil; R M Lauer
Journal:  Hum Mol Genet       Date:  1997-01       Impact factor: 6.150

7.  A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

Authors:  C L Hanis; E Boerwinkle; R Chakraborty; D L Ellsworth; P Concannon; B Stirling; V A Morrison; B Wapelhorst; R S Spielman; K J Gogolin-Ewens; J M Shepard; S R Williams; N Risch; D Hinds; N Iwasaki; M Ogata; Y Omori; C Petzold; H Rietzch; H E Schröder; J Schulze; N J Cox; S Menzel; V V Boriraj; X Chen; L R Lim; T Lindner; L E Mereu; Y Q Wang; K Xiang; K Yamagata; Y Yang; G I Bell
Journal:  Nat Genet       Date:  1996-06       Impact factor: 38.330

8.  Personality characteristics of the parents of autistic individuals.

Authors:  J Piven; M Wzorek; R Landa; J Lainhart; P Bolton; G A Chase; S Folstein
Journal:  Psychol Med       Date:  1994-08       Impact factor: 7.723

Review 9.  Translating the genetic library: the goals, methods, and applications of the Human Genome Project.

Authors:  C Keleher
Journal:  Bull Med Libr Assoc       Date:  1993-07

10.  Allelic variation of human serotonin transporter gene expression.

Authors:  A Heils; A Teufel; S Petri; G Stöber; P Riederer; D Bengel; K P Lesch
Journal:  J Neurochem       Date:  1996-06       Impact factor: 5.372
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  6 in total

1.  Chromosome 7q: where autism meets language disorder?

Authors:  S E Folstein; R E Mankoski
Journal:  Am J Hum Genet       Date:  2000-07-07       Impact factor: 11.025

2.  Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families.

Authors:  Maricela Alarcón; Rita M Cantor; Jianjun Liu; T Conrad Gilliam; Daniel H Geschwind
Journal:  Am J Hum Genet       Date:  2001-12-06       Impact factor: 11.025

3.  Effects of different attentional cues on responding to joint attention in younger siblings of children with autism spectrum disorders.

Authors:  Alison G Presmanes; Tedra A Walden; Wendy L Stone; Paul J Yoder
Journal:  J Autism Dev Disord       Date:  2006-12-21

4.  A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27.

Authors:  Mari Auranen; Raija Vanhala; Teppo Varilo; Kristin Ayers; Elli Kempas; Tero Ylisaukko-Oja; Janet S Sinsheimer; Leena Peltonen; Irma Järvelä
Journal:  Am J Hum Genet       Date:  2002-08-21       Impact factor: 11.025

Review 5.  Review of cluster analysis of phenotypic data in Autism Spectrum Disorders: distinct subtypes or a severity gradient model?

Authors:  Christine K Syriopoulou-Delli; Elpis Papaefstathiou
Journal:  Int J Dev Disabil       Date:  2019-01-15

6.  The relationship between temperament and autistic traits in a non-clinical students sample.

Authors:  Ewa Pisula; Rafał Kawa; Dorota Danielewicz; Wojciech Pisula
Journal:  PLoS One       Date:  2015-04-10       Impact factor: 3.240
  6 in total

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