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Literature DB >> 7668301

Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.

A Pickles¹, P Bolton, H Macdonald, A Bailey, A Le Couteur, C H Sim, M Rutter.

Abstract

The use of the family history method to examine the pattern of recurrence risks for complex disorders such as autism is not straightforward. Problems such as uncertain phenotypic definition, unreliable measurement with increased error rates for more distant relatives, and selection due to reduced fertility all complicate the estimation of risk ratios. Using data from a recent family history study of autism, and a similar study of twins, this paper shows how a latent-class approach can be used to tackle these problems. New findings are presented supporting a multiple-locus model of inheritance, with three loci giving the best fit.

Entities: Disease

Mesh：

Year: 1995 PMID： 7668301 PMCID： PMC1801262

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

21 in total

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Authors: S L Smalley; R F Asarnow; M A Spence
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10. Behaviour problems in retarded children with special reference to Down's syndrome.

Authors: A Gath; D Gumley
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96 in total

1. A genomic screen of autism: evidence for a multilocus etiology.

Authors: N Risch; D Spiker; L Lotspeich; N Nouri; D Hinds; J Hallmayer; L Kalaydjieva; P McCague; S Dimiceli; T Pitts; L Nguyen; J Yang; C Harper; D Thorpe; S Vermeer; H Young; J Hebert; A Lin; J Ferguson; C Chiotti; S Wiese-Slater; T Rogers; B Salmon; P Nicholas; P B Petersen; C Pingree; W McMahon; D L Wong; L L Cavalli-Sforza; H C Kraemer; R M Myers
Journal: Am J Hum Genet Date: 1999-08 Impact factor: 11.025

Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism.

1. The calculation of morbid risk in parents of index cases, as applied to a family sample of schizophrenics.

2. Report of the Committee on Methods of Linkage Analysis and Reporting.

3. The family history approach to diagnosis. How useful is it?

4. Genetic influences and infantile autism.

5. Relative risks of diseases in the presence of incomplete penetrance and sporadics.

6. Estimating morbidity risks in relatives: the effect of reduced fertility.

7. An evaluation of the family history method for ascertaining psychiatric disorders.

8. Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals.

Review 9. Autism and genetics. A decade of research.

10. Behaviour problems in retarded children with special reference to Down's syndrome.

1. A genomic screen of autism: evidence for a multilocus etiology.

Review 2. Genetic studies of autism: from the 1970s into the millennium.

Review 3. Heterogeneity and the genetics of autism.

4. Chromosome 7q: where autism meets language disorder?

5. Proteomic approach for the elucidation of biological defects in autism.

6. Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity.

Review 7. Autism: current theories regarding its pathogenesis and implications for rational pharmacotherapy.

8. Medical disorders among inpatients with autism in Denmark according to ICD-8: a nationwide register-based study.

Review 9. Autism: in search of susceptibility genes.

10. Patterns of youth tobacco and polytobacco usage: The shift to alternative tobacco products.