Literature DB >> 9813354

Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.

N Chevassus-au-Louis1, Y Ben-Ari, M Vergnes.   

Abstract

In humans, cortical malformations are highly epileptogenic. In rats, prenatal treatment with methylazoxymethanol (MAM) cause a diffuse cortical malformation that is yet not associated with seizures. We performed rapid hippocampal kindling in MAM and control rats. We show that MAM rats present (i) a lower initial afterdischarge threshold; (ii) a more rapid progression to generalized seizures. We conclude that MAM rats may serve as models for human epileptogenic cortical malformations. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9813354     DOI： 10.1016/s0006-8993(98)00932-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

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2.  Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia.

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Journal:  Brain Res       Date:  2011-01-20       Impact factor: 3.252

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5.  Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy.

Authors:  P A Castro; E C Cooper; D H Lowenstein; S C Baraban
Journal:  J Neurosci       Date:  2001-09-01       Impact factor: 6.167

Review 6.  Cerebrovascular remodeling and epilepsy.

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7.  Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications.

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8.  Combined effects of prenatal inhibition of vasculogenesis and neurogenesis on rat brain development.

Authors:  Q Y Fan; S Ramakrishna; N Marchi; Vincent Fazio; Kerri Hallene; D Janigro
Journal:  Neurobiol Dis       Date:  2008-09-30       Impact factor: 5.996

Review 9.  Modeling epileptic spasms during infancy: Are we heading for the treatment yet?

Authors:  Libor Velíšek; Jana Velíšková
Journal:  Pharmacol Ther       Date:  2020-05-15       Impact factor: 12.310

10.  Enrichment and training improve cognition in rats with cortical malformations.

Authors:  Kyle R Jenks; Marcella M Lucas; Ben A Duffy; Ashlee A Robbins; Barjor Gimi; Jeremy M Barry; Rod C Scott
Journal:  PLoS One       Date:  2013-12-17       Impact factor: 3.240
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