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Literature DB >> 19761452

Animal models of focal cortical dysplasia and tuberous sclerosis complex: recent progress toward clinical applications.

Abstract

Focal cortical dysplasia (FCD) and related malformations of cortical development (MCDs) represent an increasingly recognized cause of medically intractable epilepsy. However, the underlying mechanisms of epileptogenesis are poorly understood, and treatments for epilepsy due to various cortical malformations are often limited or ineffective. Animal models offer a number of advantages for investigating cellular and molecular mechanisms of epileptogenesis and developing novel, rational therapies for MCD-related epilepsy. This review highlights specific examples of how animal models have been useful in addressing several clinically relevant issues about epilepsy due to FCDs and related cortical malformations, including the pathologic and clinical features, etiologic factors, localization of the epileptogenic zone, neuronal and astrocytic contributions to epileptogenesis, and the development of antiepileptogenic therapies.

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Year: 2009 PMID： 19761452 PMCID： PMC3934654 DOI： 10.1111/j.1528-1167.2009.02295.x

Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 5.864

54 in total

1. Electroencephalographic characterization of an adult rat model of radiation-induced cortical dysplasia.

Authors: S Kondo; I Najm; T Kunieda; S Perryman; K Yacubova; H O Lüders
Journal: Epilepsia Date: 2001-10 Impact factor: 5.864

2. Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia.

Authors: P B Crino; A C Duhaime; G Baltuch; R White
Journal: Neurology Date: 2001-04-10 Impact factor: 9.910

3. Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling.

Authors: Xinsheng Gao; Yong Zhang; Peter Arrazola; Okio Hino; Toshiyuki Kobayashi; Raymond S Yeung; Binggeng Ru; Duojia Pan
Journal: Nat Cell Biol Date: 2002-09 Impact factor: 28.824

4. Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

Authors: Erik J Uhlmann; Michael Wong; Rebecca L Baldwin; M Livia Bajenaru; Hiroaki Onda; David J Kwiatkowski; Kelvin Yamada; David H Gutmann
Journal: Ann Neurol Date: 2002-09 Impact factor: 10.422

5. Altered corticogenesis and neuronal morphology in irradiation-induced cortical dysplasia: a Golgi-Cox study.

Authors: Miguel Marín-Padilla; Regina J Tsai; Michael A King; Steven N Roper
Journal: J Neuropathol Exp Neurol Date: 2003-11 Impact factor: 3.685

6. Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome.

Authors: L Tassi; N Colombo; R Garbelli; S Francione; G Lo Russo; R Mai; F Cardinale; M Cossu; A Ferrario; C Galli; M Bramerio; A Citterio; R Spreafico
Journal: Brain Date: 2002-08 Impact factor: 13.501

7. Impaired glial glutamate transport in a mouse tuberous sclerosis epilepsy model.

Authors: Michael Wong; Kevin C Ess; Erik J Uhlmann; Laura A Jansen; Wen Li; Peter B Crino; Steven Mennerick; Kelvin A Yamada; David H Gutmann
Journal: Ann Neurol Date: 2003-08 Impact factor: 10.422

8. Focal cortical dysplasia and intractable epilepsy in adults: clinical, EEG, imaging, and surgical features.

Authors: Jocelyn F Bautista; Nancy Foldvary-Schaefer; William E Bingaman; Hans O Lüders
Journal: Epilepsy Res Date: 2003 Jun-Jul Impact factor: 3.045

9. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo.

Authors: Chang-Hyuk Kwon; Xiaoyan Zhu; Junyuan Zhang; Suzanne J Baker
Journal: Proc Natl Acad Sci U S A Date: 2003-10-08 Impact factor: 11.205

10. Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia.

Authors: Eleonora Aronica; Jan A Gorter; Gerard H Jansen; Cees W M van Veelen; Peter C van Rijen; Marja Ramkema; Dirk Troost
Journal: Epilepsia Date: 2003-06 Impact factor: 5.864

11 in total

Review 1. Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy.

Authors: Uwe Heinemann; Daniela Kaufer; Alon Friedman
Journal: Glia Date: 2012-02-29 Impact factor: 7.452

2. Activation of extracellular regulated kinase and mechanistic target of rapamycin pathway in focal cortical dysplasia.

Authors: Vinit V Patil; Miguel Guzman; Angela N Carter; Geetanjali Rathore; Daniel Yoshor; Daniel Curry; Angus Wilfong; Satish Agadi; John W Swann; Adekunle M Adesina; Meenakshi B Bhattacharjee; Anne E Anderson
Journal: Neuropathology Date: 2015-09-18 Impact factor: 1.906

3. Enhanced infragranular and supragranular synaptic input onto layer 5 pyramidal neurons in a rat model of cortical dysplasia.

Authors: Julia Brill; John R Huguenard
Journal: Cereb Cortex Date: 2010-03-25 Impact factor: 5.357

4. Bayesian network and mechanistic hierarchical structure modeling of increased likelihood of developing intractable childhood epilepsy from the combined effect of mtDNA variants, oxidative damage, and copy number.

Authors: Brenda Luna; Sanjiv Bhatia; Changwon Yoo; Quentin Felty; David I Sandberg; Michael Duchowny; Ziad Khatib; Ian Miller; John Ragheb; Jayakar Prasanna; Deodutta Roy
Journal: J Mol Neurosci Date: 2014-07-16 Impact factor: 3.444

Review 5. Past and present definitions of epileptogenesis and its biomarkers.

Authors: Asla Pitkänen; Jerome Engel
Journal: Neurotherapeutics Date: 2014-04 Impact factor: 7.620

6. Rats with Malformations of Cortical Development Exhibit Decreased Length of AIS and Hypersensitivity to Pilocarpine-Induced Status Epilepticus.

Authors: Yelan Wang; Danni Sun; Zongwei Yue; Weiting Tang; Bo Xiao; Li Feng
Journal: Neurochem Res Date: 2016-06-10 Impact factor: 3.996