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Literature DB >> 9808620

Activation of Rac1 by a Crk SH3-binding protein, DOCK180.

E Kiyokawa¹, Y Hashimoto, S Kobayashi, H Sugimura, T Kurata, M Matsuda.

Abstract

DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of CrkII and p130(Cas) enhanced this DOCK180-dependent activation of Rac1. Furthermore, we observed direct binding of DOCK180 to Rac1, but not to RhoA or Cdc42Hs. Dominant-negative Rac1 suppressed DOCK180-induced membrane spreading. These results strongly suggest that DOCK180 is a novel activator of Rac1 and involved in integrin signaling.

Entities: Chemical Gene Species

Mesh：

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Year: 1998 PMID： 9808620 PMCID： PMC317231 DOI： 10.1101/gad.12.21.3331

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

35 in total

Review 1. The Dbl family of oncogenes.

Authors: R A Cerione; Y Zheng
Journal: Curr Opin Cell Biol Date: 1996-04 Impact factor: 8.382

2. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

Authors: H Hasegawa; E Kiyokawa; S Tanaka; K Nagashima; N Gotoh; M Shibuya; T Kurata; M Matsuda
Journal: Mol Cell Biol Date: 1996-04 Impact factor: 4.272

3. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.

Authors: P T Hawkins; A Eguinoa; R G Qiu; D Stokoe; F T Cooke; R Walters; S Wennström; L Claesson-Welsh; T Evans; M Symons
Journal: Curr Biol Date: 1995-04-01 Impact factor: 10.834

4. Rho family GTPases bind to phosphoinositide kinases.

Authors: K F Tolias; L C Cantley; C L Carpenter
Journal: J Biol Chem Date: 1995-07-28 Impact factor: 5.157

5. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.

Authors: O A Coso; M Chiariello; J C Yu; H Teramoto; P Crespo; N Xu; T Miki; J S Gutkind
Journal: Cell Date: 1995-06-30 Impact factor: 41.582

6. Interaction of ect2 and Dbl with Rho-related GTPases.

Authors: T Miki
Journal: Methods Enzymol Date: 1995 Impact factor: 1.600

7. A role for Rac in Tiam1-induced membrane ruffling and invasion.

Authors: F Michiels; G G Habets; J C Stam; R A van der Kammen; J G Collard
Journal: Nature Date: 1995-05-25 Impact factor: 49.962

8. Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro.

Authors: M Hart; S Powers
Journal: Methods Enzymol Date: 1995 Impact factor: 1.600

9. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.

Authors: K Vuori; H Hirai; S Aizawa; E Ruoslahti
Journal: Mol Cell Biol Date: 1996-06 Impact factor: 4.272

10. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G.

Authors: T Gotoh; S Hattori; S Nakamura; H Kitayama; M Noda; Y Takai; K Kaibuchi; H Matsui; O Hatase; H Takahashi
Journal: Mol Cell Biol Date: 1995-12 Impact factor: 4.272

130 in total

Review 1. Coordinating cell fate and morphogenesis in Drosophila renal tubules.

Authors: C Ainsworth; S Wan; H Skaer
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2000-07-29 Impact factor: 6.237

2. Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.

Authors: Y Otsuki; M Tanaka; S Yoshii; N Kawazoe; K Nakaya; H Sugimura
Journal: Proc Natl Acad Sci U S A Date: 2001-03-27 Impact factor: 11.205

3. Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.

Authors: Ken-Ichiro Nagashima; Akira Endo; Hisakazu Ogita; Akiko Kawana; Akiko Yamagishi; Akira Kitabatake; Michiyuki Matsuda; Naoki Mochizuki
Journal: Mol Biol Cell Date: 2002-12 Impact factor: 4.138

Activation of Rac1 by a Crk SH3-binding protein, DOCK180.

Review 1. The Dbl family of oncogenes.

2. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

3. PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase.

4. Rho family GTPases bind to phosphoinositide kinases.

5. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.

6. Interaction of ect2 and Dbl with Rho-related GTPases.

7. A role for Rac in Tiam1-induced membrane ruffling and invasion.

8. Ras-Cdc25 and Rho-Dbl binding assays: complex formation in vitro.

9. Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases.

10. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G.

Review 1. Coordinating cell fate and morphogenesis in Drosophila renal tubules.

2. Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.

3. Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.

Review 4. The integrin-actin connection, an eternal love affair.

5. DIP (mDia interacting protein) is a key molecule regulating Rho and Rac in a Src-dependent manner.

6. Adhesion dynamics at a glance.

7. Opening up on ELMO regulation: New insights into the control of Rac signaling by the DOCK180/ELMO complex.

8. Rac1 is essential for basement membrane-dependent epiblast survival.

Review 9. Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression.

10. Mechanisms of CAS substrate domain tyrosine phosphorylation by FAK and Src.