Literature DB >> 980372

Repair excision of alkylated bases from DNA in vivo.

P Kleihues, H K Cooper.   

Abstract

Recent experiments are reviewed which indicate that O6-alkylation of guanine in nuclear DNA constitutes a promutagenic lesion possibly implicated in malignant transformation by monofunctional alkylating carcinogens. The differential capacity of various organs to enzymically excise O6-alkylguanine from their DNA seems to correlate with the organ specificity of the carcinogenic effect.

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Year:  1976        PMID： 980372     DOI： 10.1159/000225111

Source DB:  PubMed          Journal:  Oncology        ISSN： 0030-2414            Impact factor:   2.935


  3 in total

1.  Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography.

Authors:  J V Frei; D H Swenson; W Warren; P D Lawley
Journal:  Biochem J       Date:  1978-09-15       Impact factor: 3.857

2.  The cytotoxic effect of ethylnitrosourea on the developing rat cerebellum. Morphologic observations.

Authors:  R E Johnson; R J Campbell; E R Laws
Journal:  Acta Neuropathol       Date:  1981       Impact factor: 17.088

3.  [On the carcinogenetic action of N-nitroso compounds. 7th communication: methyl-, trideuteromethyl-, ethyl-, n-propyl-, n-butyl-, acetoxymethyl-nitrosamine, and methyl-butyroxymethyl-nitrosamine (author's transl)].

Authors:  M Wiessler; M Habs; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978
  3 in total

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