Literature DB >> 151397

[On the carcinogenetic action of N-nitroso compounds. 7th communication: methyl-, trideuteromethyl-, ethyl-, n-propyl-, n-butyl-, acetoxymethyl-nitrosamine, and methyl-butyroxymethyl-nitrosamine (author's transl)].

M Wiessler, M Habs, D Schmähl.   

Abstract

The homologons alkyl-acetoxymethyl-nitrosamines were tested for carcinogenicity in SD rats. All compounds were found to be carcinogenic and induced within the same time carcinomas of the forestomach. The total doses necessary for induction of tumors are related to the length of the alkyl chain and hence to the watersolubility. These results are discussed.

Entities:  

Mesh:

Substances:

Year:  1978        PMID: 151397     DOI: 10.1007/bf00312293

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN: 0084-5353


  15 in total

1.  Alpha-acetoxy-dimethylnitrosamine: a proximate metabolite of the carcinogenic amine.

Authors:  O G Fahmy; M J Fahmy; M Wiessler
Journal:  Biochem Pharmacol       Date:  1975-05-15       Impact factor: 5.858

2.  Metabolic degradation of stable-isotope-labelled dimethylnitrosamine by rat liver.

Authors:  R C Cottrell; B G Lake; J C Phillips; S D Gangolli
Journal:  Biochem Soc Trans       Date:  1977       Impact factor: 5.407

3.  The hepatic metabolism of 15N labelled dimethylnitrosamine in the rat.

Authors:  R C Cottrell; B G Lake; J C Phillips; S D Gangolli
Journal:  Biochem Pharmacol       Date:  1977-04-15       Impact factor: 5.858

4.  Protein bound carboxyl-methyl ester as a precursor of methanol formation during oxidation of dimethylnitrosamine in vitro.

Authors:  S Kim; P D Lotlikar; W Chin; P N Magee
Journal:  Cancer Lett       Date:  1977-03       Impact factor: 8.679

5.  Microsomal metabolism of dimethylnitrosamine and the cytochrome P-450 dependency of its activation to a mutagen.

Authors:  P Czygan; H Greim; A J Garro; F Hutterer; F Schaffner; H Popper; O Rosenthal; D Y Cooper
Journal:  Cancer Res       Date:  1973-11       Impact factor: 12.701

6.  [On the carcinogenic action of N-nitroso-compounds. 5th Communication: acetoxymethyl-methyl-nitrosamine (author's transl)].

Authors:  M Wiessler; D Schmähl
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-01-02

7.  [Metabolism of nitrosamines in vivo. I. Evidence for -oxydation of aliphatic di-n-alkylnitrosamines: the stimultaneous formation of 7-methylguanine besides 7-propyl- or 7-butylguanine after application of di-n-propyl- or di-n-butylnitrosamine].

Authors:  F W Krüger
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1971

8.  Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea.

Authors:  D H Swenson; P B Farmer; P D Lawley
Journal:  Chem Biol Interact       Date:  1976-09       Impact factor: 5.192

9.  Carcinogenicity of nitrosoazetidine and tetradeuteronitrosoazetidine in Sprague-Dawley Rats.

Authors:  W Lijinsky; H W Taylor
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-06-27

10.  Selective induction of intestinal tumors in rats by methyl(acetoxymethyl)nitrosamine, an ester of the presumed reactive metabolite of dimethylnitrosamine.

Authors:  S R Joshi; J M Rice; M L Wenk; P P Roller; L K Keefer
Journal:  J Natl Cancer Inst       Date:  1977-05       Impact factor: 13.506

View more
  3 in total

1.  N-nitrosamino phosphates are unlikely transport forms for activated nitrosamines.

Authors:  E Frei; N Frank; M Wiessler
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

2.  Interference of acetoxyalkyl-nitrosamines with limb bud differentiation in organ culture.

Authors:  R Stahlmann; U Bluth; M Wiessler; D Neubert
Journal:  Arch Toxicol       Date:  1983-10       Impact factor: 5.153

3.  Carcinogenicity of N-alkyl-N-(acetoxymethyl)nitrosamines after subcutaneous injections in F-344 rats.

Authors:  A Maekawa; T Ogiu; H Onodera; K Furuta; C Matsuoka; M Mochizuki; T Anjo; M Okada; S Odashima
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.