| Literature DB >> 9796145 |
M L Nevins1, N Y Karimbux, H P Weber, W V Giannobile, J P Fiorellini.
Abstract
Wound healing has been shown to be altered in diabetes mellitus. The aim of this study was to identify the effects of streptozotocin-induced diabetes on osseointegration. Diabetes was induced in 40-day-old rats by intraperitoneal injection of 70 mg per kg streptozotocin. At 14 days postinjection, implants were placed in the femora of 10 diabetic and 10 age-matched normal rats. Animals were sacrificed at 28 and 56 days following implantation. Histometric results indicated that the quantity of bone formation was similar for diabetic and control animals (P > .05). However, less bone-implant contact was observed for diabetic compared to control animals at both 28 and 56 days (P < .0001). This study demonstrates that the process of osseointegration is affected by streptozotocin-induced diabetes.Entities:
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Year: 1998 PMID： 9796145
Source DB: PubMed Journal: Int J Oral Maxillofac Implants ISSN： 0882-2786 Impact factor: 2.804