Literature DB >> 26009923

Effect of targeted delivery of bone morphogenetic protein-2 on bone formation in type 1 diabetes.

Ronaldo Barcellos de Santana, Phillip C Trackman.   

Abstract

PURPOSE: Bone formation and healing are diminished in experimental type 1 diabetes. The present study investigated whether controlled local release of recombinant human bone morphogenetic protein 2 (rhBMP-2) stimulates bone defect healing in diabetes as a consequence of its anabolic effects on bone.
MATERIALS AND METHODS: Bilateral experimental circular bone defects were created in the temporal bones of 64 BALB/cByJ mice. Defects were treated with acellular collagen sponge plus 0.4 or 1.8 μg of rhBMP-2 per defect, and untreated defects served as controls. The healing of the defects over a 14-day period in diabetic and nondiabetic mice was analyzed histomorphometrically.
RESULTS: Diabetes inhibited bone formation in both untreated and BMP-treated bone defects. Controlled local release of rhBMP-2 significantly stimulated bone formation in diabetic animals, bringing it nearly to normal levels, and enhanced bone regeneration in normal animals.
CONCLUSION: Recombinant human BMP-2 may be beneficial in treating deficient intramembranous bone formation in diabetes.

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Year:  2015        PMID： 26009923      PMCID： PMC4472391          DOI： 10.11607/jomi.3956

Source DB:  PubMed          Journal:  Int J Oral Maxillofac Implants        ISSN： 0882-2786            Impact factor:   2.804


  63 in total

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2.  Diabetic bone disease.

Authors:  R Bouillon
Journal:  Calcif Tissue Int       Date:  1991-09       Impact factor: 4.333

3.  Suggestion of a deficient osteoblastic function in diabetes mellitus: the possible cause of osteopenia in diabetics.

Authors:  H Rico; E R Hernandez; J A Cabranes; F Gomez-Castresana
Journal:  Calcif Tissue Int       Date:  1989-08       Impact factor: 4.333

4.  Effect of streptozotocin-induced diabetes mellitus on alveolar bone deposition in the rat.

Authors:  Naoyuki Mishima; Noriyuki Sahara; Masayori Shirakawa; Hidehiro Ozawa
Journal:  Arch Oral Biol       Date:  2002-12       Impact factor: 2.633

5.  Bone formation around titanium implants in the rat tibia: role of insulin.

Authors:  José T Siqueira; Simone C Cavalher-Machado; Victor E Arana-Chavez; Paulina Sannomiya
Journal:  Implant Dent       Date:  2003       Impact factor: 2.454

6.  Histomorphometric evaluation of the influence of the diabetic metabolic state on bone defect healing depending on the defect size in spontaneously diabetic BB/OK rats.

Authors:  Niels Follak; Ingrid Klöting; Eduard Wolf; Harry Merk
Journal:  Bone       Date:  2004-07       Impact factor: 4.398

7.  Osteodystrophy of diabetics in chronic dialysis: a histomorphometric study.

Authors:  J Aubia; S Serrano; L Mariñoso; L Hojman; A Diez; J Lloveras; J Masramon
Journal:  Calcif Tissue Int       Date:  1988-05       Impact factor: 4.333

8.  The influence of diabetes mellitus and insulin therapy on biomechanical retention around dental implants: a study in rabbits.

Authors:  Rogério Margonar; Celso E Sakakura; Marinella Holzhausen; Maria Teresa Pepato; júnior Rodolfo Cândia Alba; júnior Elcio Marcantonio
Journal:  Implant Dent       Date:  2003       Impact factor: 2.454

9.  Diabetic bone disease. Low turnover osteoporosis related to decreased IGF-I production.

Authors:  R Bouillon
Journal:  Verh K Acad Geneeskd Belg       Date:  1992

10.  Recombinant human bone morphogenetic protein-2 is superior to demineralized bone matrix in repairing craniotomy defects in rats.

Authors:  L J Marden; J O Hollinger; A Chaudhari; T Turek; R G Schaub; E Ron
Journal:  J Biomed Mater Res       Date:  1994-10
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  5 in total

1.  Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus.

Authors:  Zhiai Hu; Chi Ma; Xin Rong; Shujuan Zou; Xiaohua Liu
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2.  Orchestration of energy metabolism and osteogenesis by Mg2+ facilitates low-dose BMP-2-driven regeneration.

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Journal:  Bioact Mater       Date:  2022-03-24

Review 3.  Pathogenesis and treatment of wound healing in patients with diabetes after tooth extraction.

Authors:  Shuting Yang; You Li; Chengcheng Liu; Yafei Wu; Zixin Wan; Daonan Shen
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-23       Impact factor: 6.055

4.  Chrysin Attenuates High Glucose-Induced BMSC Dysfunction via the Activation of the PI3K/AKT/Nrf2 Signaling Pathway.

Authors:  Yu Li; Ximei Wang
Journal:  Drug Des Devel Ther       Date:  2022-01-13       Impact factor: 4.162

Review 5.  Potential Functions of the BMP Family in Bone, Obesity, and Glucose Metabolism.

Authors:  Yao Chen; Bingwei Ma; Xingchun Wang; Xiaojuan Zha; Chunjun Sheng; Peng Yang; Shen Qu
Journal:  J Diabetes Res       Date:  2021-06-23       Impact factor: 4.011
  5 in total

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