Literature DB >> 9794818

Hypoxia-inducible factor 1: master regulator of O2 homeostasis.

G L Semenza1.   

Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates essential homeostatic responses to reduced O2 availability in mammals. Recent studies have provided insights into the O2-dependent regulation of HIF-1 expression, target genes regulated by HIF-1, and the effects of HIF-1 deficiency on cellular physiology and embryonic development.

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Year:  1998        PMID： 9794818     DOI： 10.1016/s0959-437x(98)80016-6

Source DB:  PubMed          Journal:  Curr Opin Genet Dev        ISSN： 0959-437X            Impact factor:   5.578


  279 in total

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