Literature DB >> 10554089

Therapeutic targets for hypoxia-elicited pathways.

C T Taylor1, S P Colgan.   

Abstract

Diminished oxygen supply to tissues (hypoxia) can stem from many sources, and is a contributing factor to diverse disease processes. Cell and tissue responses to hypoxia are diverse and include dramatic changes in metabolic demand, regulation of cellular gene products, and release of lipid and protein mediators. Surprisingly little attention has been paid to targeted development of therapeutics for hypoxia-related disease processes. This review will focus on recent advances in cellular and molecular biology pertaining to the hypoxia response, and will discuss paradigms used to study hypoxia and the potential targets for therapeutic intervention.

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Year:  1999        PMID： 10554089     DOI： 10.1023/a:1011936016833

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  93 in total

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Journal:  Curr Opin Cardiol       Date:  1998-09       Impact factor: 2.161

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Journal:  Ann N Y Acad Sci       Date:  1997-12-15       Impact factor: 5.691

3.  Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

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4.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

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Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

Review 5.  Oxygen sensing and molecular adaptation to hypoxia.

Authors:  H F Bunn; R O Poyton
Journal:  Physiol Rev       Date:  1996-07       Impact factor: 37.312

6.  Lipoxin B4 regulates human monocyte/neutrophil adherence and motility: design of stable lipoxin B4 analogs with increased biologic activity.

Authors:  J F Maddox; S P Colgan; C B Clish; N A Petasis; V V Fokin; C N Serhan
Journal:  FASEB J       Date:  1998-04       Impact factor: 5.191

7.  Angiostatin induces and sustains dormancy of human primary tumors in mice.

Authors:  M S O'Reilly; L Holmgren; C Chen; J Folkman
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

8.  Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

Authors:  M Karakurum; R Shreeniwas; J Chen; D Pinsky; S D Yan; M Anderson; K Sunouchi; J Major; T Hamilton; K Kuwabara; A Rot; R Nowygrod; D Stern
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

9.  Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia.

Authors:  K Sogawa; K Numayama-Tsuruta; M Ema; M Abe; H Abe; Y Fujii-Kuriyama
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-23       Impact factor: 11.205

10.  The nitric oxide/cyclic GMP pathway in organ transplantation: critical role in successful lung preservation.

Authors:  D J Pinsky; Y Naka; N C Chowdhury; H Liao; M C Oz; R E Michler; E Kubaszewski; T Malinski; D M Stern
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205
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  10 in total

1.  Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26.

Authors:  Holger K Eltzschig; Marion Faigle; Simone Knapp; Jorn Karhausen; Juan Ibla; Peter Rosenberger; Kirsten C Odegard; Peter C Laussen; Linda F Thompson; Sean P Colgan
Journal:  Blood       Date:  2006-05-02       Impact factor: 22.113

2.  Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia.

Authors:  C T Taylor; G T Furuta; K Synnestvedt; S P Colgan
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

3.  Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

Authors:  Jörn Karhausen; Glenn T Furuta; John E Tomaszewski; Randall S Johnson; Sean P Colgan; Volker H Haase
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

4.  Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.

Authors:  Katrina M Comerford; Martin O Leonard; Jorn Karhausen; Robyn Carey; Sean P Colgan; Cormac T Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-27       Impact factor: 11.205

5.  Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body.

Authors:  Siu-Yin Lam; George L Tipoe; Emily C Liong; Man-Lung Fung
Journal:  Histochem Cell Biol       Date:  2008-05-01       Impact factor: 4.304

6.  Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.

Authors:  Tianqing Kong; Holger K Eltzschig; Jorn Karhausen; Sean P Colgan; C Simon Shelley
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-02       Impact factor: 11.205

7.  Hypoxia-inducible factor 1-dependent induction of intestinal trefoil factor protects barrier function during hypoxia.

Authors:  G T Furuta; J R Turner; C T Taylor; R M Hershberg; K Comerford; S Narravula; D K Podolsky; S P Colgan
Journal:  J Exp Med       Date:  2001-05-07       Impact factor: 14.307

Review 8.  Pathogenic roles of the carotid body inflammation in sleep apnea.

Authors:  Man Lung Fung
Journal:  Mediators Inflamm       Date:  2014-09-07       Impact factor: 4.711

9.  Dietary Copper Plays an Important Role in Maintaining Intestinal Barrier Integrity During Alcohol-Induced Liver Disease Through Regulation of the Intestinal HIF-1α Signaling Pathway and Oxidative Stress.

Authors:  Hongwei Lin; Dazhi Chen; Qianjing Du; Tongtong Pan; Hanxiao Tu; Yuedong Xu; Teng Teng; Jingjing Tu; Ji Li; Zhuo Lin; Xiaodong Wang; Lanman Xu; Yong-Ping Chen
Journal:  Front Physiol       Date:  2020-05-08       Impact factor: 4.566

10.  Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors.

Authors:  Holger K Eltzschig; Juan C Ibla; Glenn T Furuta; Martin O Leonard; Kenneth A Jacobson; Keiichi Enjyoji; Simon C Robson; Sean P Colgan
Journal:  J Exp Med       Date:  2003-08-25       Impact factor: 14.307
  10 in total

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