Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics.

Literature DB >> 9791136

Induction of ermAMR from a clinical strain of Enterococcus faecalis by 16-membered-ring macrolide antibiotics.

Abstract

We cloned the MLSB resistance determinant by PCR from a clinical isolate of Enterococcus faecalis 373, which is induced more strongly by a 16-membered-ring macrolide, tylosin, than by erythromycin. To elucidate the molecular basis of resistance of E. faecalis 373, we analyzed the cloned gene, designated ermAMR, by site-directed mutagenesis and reporter gene assay. Our results showed that an arginine-to-cysteine change in the seventh codon of the putative leader peptide endowed tylosin with resistance inducibility and that TAAA duplication enabled the control region to express the downstream methylase gene at a drastically increased level.

Entities: Chemical Species

Mesh：

Substances：

Year: 1998 PMID： 9791136 PMCID： PMC107645

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

22 in total

1. REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.

Authors: C Anagnostopoulos; J Spizizen
Journal: J Bacteriol Date: 1961-05 Impact factor: 3.490

2. Macrolide-lincosamide-streptogramin B resistance in Staphylococcus lentus results from the integration of part of a transposon into a small plasmid.

Authors: C Werckenthin; S Schwarz; K Dyke
Journal: Antimicrob Agents Chemother Date: 1996-09 Impact factor: 5.191

3. The ermC leader peptide: amino acid alterations leading to differential efficiency of induction by macrolide-lincosamide-streptogramin B antibiotics.

Authors: M Mayford; B Weisblum
Journal: J Bacteriol Date: 1990-07 Impact factor: 3.490

4. Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol.

Authors: S B Taubman; N R Jones; F E Young; J W Corcoran
Journal: Biochim Biophys Acta Date: 1966-08-17

5. Chromosomal location of genes regulating resistance to bacteriophage in Bacillus subtilis.

Authors: F E Young; C Smith; B E Reilly
Journal: J Bacteriol Date: 1969-06 Impact factor: 3.490

6. Transcriptional attenuation control of ermK, a macrolide-lincosamide-streptogramin B resistance determinant from Bacillus licheniformis.

Authors: J H Kwak; E C Choi; B Weisblum
Journal: J Bacteriol Date: 1991-08 Impact factor: 3.490

7. Erythromycin-inducible resistance in Staphylococcus aureus: requirements for induction.

Authors: B Weisblum; C Siddhikol; C J Lai; V Demohn
Journal: J Bacteriol Date: 1971-06 Impact factor: 3.490

8. Bacillus subtilis requires a "stringent" Shine-Dalgarno region for gene expression.

Authors: L Band; D J Henner
Journal: DNA Date: 1984

9. Complete nucleotide sequence of macrolide-lincosamide-streptogramin B-resistance transposon Tn917 in Streptococcus faecalis.

Authors: J H Shaw; D B Clewell
Journal: J Bacteriol Date: 1985-11 Impact factor: 3.490

10. Transposon Tn554: complete nucleotide sequence and isolation of transposition-defective and antibiotic-sensitive mutants.

Authors: E Murphy; L Huwyler; M do C de Freire Bastos
Journal: EMBO J Date: 1985-12-01 Impact factor: 11.598

12 in total

Review 1. Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Authors: M C Roberts; J Sutcliffe; P Courvalin; L B Jensen; J Rood; H Seppala
Journal: Antimicrob Agents Chemother Date: 1999-12 Impact factor: 5.191

2. Heterogeneity of macrolide-lincosamide-streptogramin B resistance phenotypes in enterococci.

Authors: Yu-Hong Min; Jae-Hee Jeong; Yun-Jeong Choi; Hee-Jeong Yun; Kyungwon Lee; Mi-Ja Shim; Jin-Hwan Kwak; Eung-Chil Choi
Journal: Antimicrob Agents Chemother Date: 2003-11 Impact factor: 5.191

Review 3. Modes and modulations of antibiotic resistance gene expression.

Authors: Florence Depardieu; Isabelle Podglajen; Roland Leclercq; Ekkehard Collatz; Patrice Courvalin
Journal: Clin Microbiol Rev Date: 2007-01 Impact factor: 26.132

4. Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors.

Authors: Lisa K Smith; Alexander S Mankin
Journal: Antimicrob Agents Chemother Date: 2008-02-25 Impact factor: 5.191

5. Pheromone-responsive conjugative vancomycin resistance plasmids in Enterococcus faecalis isolates from humans and chicken feces.

Authors: Suk-Kyung Lim; Koichi Tanimoto; Haruyoshi Tomita; Yasuyoshi Ike
Journal: Appl Environ Microbiol Date: 2006-10 Impact factor: 4.792

6. Characterization of ermB gene transposition by Tn1545 and Tn917 in macrolide-resistant Streptococcus pneumoniae isolates.

Authors: Naohiro Okitsu; Satoru Kaieda; Hisakazu Yano; Ryuichi Nakano; Yoshio Hosaka; Ryouichi Okamoto; Toshimitsu Kobayashi; Matsuhisa Inoue
Journal: J Clin Microbiol Date: 2005-01 Impact factor: 5.948