Literature DB >> 9791133

The SecA subunit of Escherichia coli preprotein translocase is exposed to the periplasm.

J Eichler1, W Wickner.   

Abstract

SecA undergoes conformational changes during translocation, inserting domains into and across the membrane or enhancing the protease resistance of these domains. We now show that some SecA bound at SecYEG is accessible from the periplasm to a membrane-impermeant probe in cells with a permeabilized outer membrane but an intact plasma membrane.

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Year:  1998        PMID： 9791133      PMCID： PMC107642     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  44 in total

1.  Oligomeric rings of the Sec61p complex induced by ligands required for protein translocation.

Authors:  D Hanein; K E Matlack; B Jungnickel; K Plath; K U Kalies; K R Miller; T A Rapoport; C W Akey
Journal:  Cell       Date:  1996-11-15       Impact factor: 41.582

2.  Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation.

Authors:  K Nishiyama; T Suzuki; H Tokuda
Journal:  Cell       Date:  1996-04-05       Impact factor: 41.582

3.  Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme.

Authors:  F Duong; W Wickner
Journal:  EMBO J       Date:  1997-05-15       Impact factor: 11.598

4.  SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm.

Authors:  C van der Does; T den Blaauwen; J G de Wit; E H Manting; N A Groot; P Fekkes; A J Driessen
Journal:  Mol Microbiol       Date:  1996-11       Impact factor: 3.501

5.  A significant fraction of functional SecA is permanently embedded in the membrane. SecA cycling on and off the membrane is not essential during protein translocation.

Authors:  X Chen; H Xu; P C Tai
Journal:  J Biol Chem       Date:  1996-11-22       Impact factor: 5.157

6.  Evidence that KpsT, the ATP-binding component of an ATP-binding cassette transporter, is exposed to the periplasm and associates with polymer during translocation of the polysialic acid capsule of Escherichia coli K1.

Authors:  J M Bliss; R P Silver
Journal:  J Bacteriol       Date:  1997-02       Impact factor: 3.490

7.  Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation.

Authors:  J Eichler; W Wickner
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-27       Impact factor: 11.205

8.  The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase.

Authors:  J Eichler; J Brunner; W Wickner
Journal:  EMBO J       Date:  1997-05-01       Impact factor: 11.598

9.  The MalK protein of the ATP-binding cassette transporter for maltose of Escherichia coli is accessible to protease digestion from the periplasmic side of the membrane.

Authors:  E Schneider; S Hunke; S Tebbe
Journal:  J Bacteriol       Date:  1995-09       Impact factor: 3.490

10.  Procoat, the precursor of M13 coat protein, requires an electrochemical potential for membrane insertion.

Authors:  T Date; J M Goodman; W T Wickner
Journal:  Proc Natl Acad Sci U S A       Date:  1980-08       Impact factor: 11.205
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  15 in total

1.  Evaluating the oligomeric state of SecYEG in preprotein translocase.

Authors:  T L Yahr; W T Wickner
Journal:  EMBO J       Date:  2000-08-15       Impact factor: 11.598

2.  A large conformational change of the translocation ATPase SecA.

Authors:  Andrew R Osborne; William M Clemons; Tom A Rapoport
Journal:  Proc Natl Acad Sci U S A       Date:  2004-07-15       Impact factor: 11.205

Review 3.  Use of synthetic signal sequences to explore the protein export machinery.

Authors:  Eugenia M Clérico; Jenny L Maki; Lila M Gierasch
Journal:  Biopolymers       Date:  2008       Impact factor: 2.505

Review 4.  Production of active eukaryotic proteins through bacterial expression systems: a review of the existing biotechnology strategies.

Authors:  Sudhir Sahdev; Sunil K Khattar; Kulvinder Singh Saini
Journal:  Mol Cell Biochem       Date:  2007-09-12       Impact factor: 3.396

5.  Mapping of the SecA·SecY and SecA·SecG interfaces by site-directed in vivo photocross-linking.

Authors:  Sanchaita Das; Donald B Oliver
Journal:  J Biol Chem       Date:  2011-02-11       Impact factor: 5.157

6.  Substrate Proteins Take Shape at an Improved Bacterial Translocon.

Authors:  Donald Oliver
Journal:  J Bacteriol       Date:  2018-12-07       Impact factor: 3.490

Review 7.  SecA inhibitors as potential antimicrobial agents: differential actions on SecA-only and SecA-SecYEG protein-conducting channels.

Authors:  Jinshan Jin; Ying-Hsin Hsieh; Arpana S Chaudhary; Jianmei Cui; John E Houghton; Sen-Fang Sui; Binghe Wang; Phang C Tai
Journal:  FEMS Microbiol Lett       Date:  2018-08-01       Impact factor: 2.742

Review 8.  SecA: a potential antimicrobial target.

Authors:  Arpana S Chaudhary; Weixuan Chen; Jinshan Jin; Phang C Tai; Binghe Wang
Journal:  Future Med Chem       Date:  2015       Impact factor: 3.808

9.  The SecA protein deeply penetrates into the SecYEG channel during insertion, contacting most channel transmembrane helices and periplasmic regions.

Authors:  Tithi Banerjee; Zeliang Zheng; Jane Abolafia; Shelby Harper; Donald Oliver
Journal:  J Biol Chem       Date:  2017-10-06       Impact factor: 5.157

10.  Assembly of the translocase motor onto the preprotein-conducting channel.

Authors:  Spyridoula Karamanou; Vassiliki Bariami; Efrosyni Papanikou; Charalampos G Kalodimos; Anastassios Economou
Journal:  Mol Microbiol       Date:  2008-08-22       Impact factor: 3.501
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