BACKGROUND: Sickle cell disease is a serious public health problem in Gabon with a relatively high mortality rate. PATIENTS AND METHODS: Charts of 23 children (nine boys, 14 girls) who died of complications from sickle cell anemia in the department of pediatrics of Owendo Pediatric Hospital (Libreville, Gabon), from January 1, 1990 through December 31, 1992, were analysed retrospectively. RESULTS: Approximately two-thirds of the children (60.9%) were under 5 years of age. The great majority of patients were from low socio-economic standard families. Of 319 deaths observed during the study period, 23 were due to sickle cell disease-associated complications, for an overall mortality rate of 7.2% and a related mortality of 3.6%. Commonest causes of deaths were severe anemia (11 cases, i.e., 47.8%), which affected predominantly the younger patients between 6 months and 5 years (eight cases), infections (30.4%) and blood transfusion complications (21.7%). CONCLUSION: To decrease these mortality rates, appropriate health supervision and well-designed preventive strategies are needed.
BACKGROUND:Sickle cell disease is a serious public health problem in Gabon with a relatively high mortality rate. PATIENTS AND METHODS: Charts of 23 children (nine boys, 14 girls) who died of complications from sickle cell anemia in the department of pediatrics of Owendo Pediatric Hospital (Libreville, Gabon), from January 1, 1990 through December 31, 1992, were analysed retrospectively. RESULTS: Approximately two-thirds of the children (60.9%) were under 5 years of age. The great majority of patients were from low socio-economic standard families. Of 319 deaths observed during the study period, 23 were due to sickle cell disease-associated complications, for an overall mortality rate of 7.2% and a related mortality of 3.6%. Commonest causes of deaths were severe anemia (11 cases, i.e., 47.8%), which affected predominantly the younger patients between 6 months and 5 years (eight cases), infections (30.4%) and blood transfusion complications (21.7%). CONCLUSION: To decrease these mortality rates, appropriate health supervision and well-designed preventive strategies are needed.
Authors: Sophie Uyoga; Alex W Macharia; George Mochamah; Carolyne M Ndila; Gideon Nyutu; Johnstone Makale; Metrine Tendwa; Emily Nyatichi; John Ojal; Mark Otiende; Mohammed Shebe; Kennedy O Awuondo; Neema Mturi; Norbert Peshu; Benjamin Tsofa; Kathryn Maitland; J Anthony G Scott; Thomas N Williams Journal: Lancet Glob Health Date: 2019-08-23 Impact factor: 26.763
Authors: Manish Sadarangani; Julie Makani; Albert N Komba; Tolu Ajala-Agbo; Charles R Newton; Kevin Marsh; Thomas N Williams Journal: Br J Haematol Date: 2009-07-23 Impact factor: 6.998
Authors: A Al-Madhani; A Pathare; S Al Zadjali; M Al Rawahi; I Al-Nabhani; S Alkindi Journal: Mediterr J Hematol Infect Dis Date: 2019-01-01 Impact factor: 2.576