| Literature DB >> 978677 |
S M Kupchan, J A Lacadie, G A Howie, B R Sickles.
Abstract
A C-15 ester substituent is required for significant antileukemic activity among the glaucarubolone ester quassinoids, and variations in the ester group are not accompanied by particularly marked changes in antileukemic activity. Unsaturation at the 3,4 position is advantageous for optimal activity, and hydrogenation of this double bond results in marked diminution in both cytotoxicity toward KB cells in tissue culture and inhibitory activity against the P-388 lymphocytic leukemia in mice.Entities:
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Year: 1976 PMID： 978677 DOI： 10.1021/jm00231a009
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446