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Literature DB >> 86390

New natural products of interest under development at the National Cancer Institute.

Abstract

Fourteen new agents of natural products origin which are under development as antitumor agents at the National Cancer Institute are discussed with reference to their sources, structures, antitumor activity, current status, and future prospects as clinically effective agents.

Mesh：

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Year: 1978 PMID： 86390 DOI： 10.1007/BF00254042

Source DB: PubMed Journal: Cancer Chemother Pharmacol ISSN： 0344-5704 Impact factor: 3.333

16 in total

1. Baccharin, a novel potent antileukemic trichothecene triepoxide from Baccharis megapotamica.

Authors: S M Kupchan; B B Jarvis; R J Dailey; W Bright; R F Bryan; Y Shizuri
Journal: J Am Chem Soc Date: 1976-10-27 Impact factor: 15.419

Review 2. Antineoplastic agents from plants.

Authors: M E Wall; M C Wani
Journal: Annu Rev Pharmacol Toxicol Date: 1977 Impact factor: 13.820

3. U-42, 126, a new antimetabolite antibiotic: production, biological activity, and taxonomy of the producing microorganism.

Authors: L J Hanka; A Dietz
Journal: Antimicrob Agents Chemother Date: 1973-03 Impact factor: 5.191

4. Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica.

Authors: S M Kupchan; R W Britton; M F Ziegler; C W Sigel
Journal: J Org Chem Date: 1973-01-12 Impact factor: 4.354

5. Maytansine, a novel antileukemic ansa macrolide from Maytenus ovatus.

Authors: S M Kupchan; Y Komoda; W A Court; G J Thomas; R M Smith; A Karim; C J Gilmore; R C Haltiwanger; R F Bryan
Journal: J Am Chem Soc Date: 1972-02-23 Impact factor: 15.419

6. The structures of toxins from two strains of Fusarium tricinctum.

Authors: J R Bamburg; N V Riggs; F M Strong
Journal: Tetrahedron Date: 1968-04 Impact factor: 2.457

7. Structures of harringtonine, isoharringtonine, and homoharringtonine.

Authors: R G Powell; D Weisleder; C R Smith; W K Rohwedder
Journal: Tetrahedron Lett Date: 1970-03 Impact factor: 2.415

Review 8. Novel plant-derived tumor inhibitors and their mechanisms of action.

Authors: S M Kupchan
Journal: Cancer Treat Rep Date: 1976-08

9. Structural requirements for biological activity among antileukemic glaucarubolone ester quassinoids.

Authors: S M Kupchan; J A Lacadie; G A Howie; B R Sickles
Journal: J Med Chem Date: 1976-09 Impact factor: 7.446

Review 10. Types of anticancer agents isolated from plants.

Authors: J L Hartwell
Journal: Cancer Treat Rep Date: 1976-08

9 in total

1. p53-independent apoptosis induced by paclitaxel through an indirect mechanism.

Authors: J S Lanni; S W Lowe; E J Licitra; J O Liu; T Jacks
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

2. Current trends in the chemoprevention of cancer.

Authors: Fazlul H Sarkar
Journal: Pharm Res Date: 2010-04-17 Impact factor: 4.200

3. Growth-inhibiting effects of taxol on human liver cancer in vitro and in nude mice.

Authors: Jin-Hui Yuan; Ru-Ping Zhang; Ru-Gang Zhang; Li-Xia Guo; Xing-Wang Wang; Dan Luo; Yong Xie; Hong Xie
Journal: World J Gastroenterol Date: 2000-04 Impact factor: 5.742

4. The cytotoxicity of T-2 toxin and related 12,13-epoxytrichothecenes to Adriamycin-sensitive and -resistant P388 leukemia cells.

Authors: A Ramu; B Yagen; N Ramu
Journal: Cancer Chemother Pharmacol Date: 1989 Impact factor: 3.333