Literature DB >> 9786179

Structure-activity relationship studies of dynorphin A and related peptides.

T Naqvi1, W Haq, K B Mathur.   

Abstract

An up-to-date review is presented covering all the available information concerning the isolation, discovery, synthesis, conformation, receptor binding characteristics, pharmacological properties and SAR studies of dynorphin A and related peptides. The potential of dynorphin A and its analogs has yet to be fully realized.

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Year:  1998        PMID： 9786179     DOI： 10.1016/s0196-9781(98)00042-4

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  12 in total

Review 1.  The dynorphin/κ-opioid receptor system and its role in psychiatric disorders.

Authors:  H A Tejeda; T S Shippenberg; R Henriksson
Journal:  Cell Mol Life Sci       Date:  2011-10-16       Impact factor: 9.261

2.  Chemotype-selective modes of action of κ-opioid receptor agonists.

Authors:  Eyal Vardy; Philip D Mosier; Kevin J Frankowski; Huixian Wu; Vsevolod Katritch; Richard B Westkaemper; Jeffrey Aubé; Raymond C Stevens; Bryan L Roth
Journal:  J Biol Chem       Date:  2013-10-11       Impact factor: 5.157

3.  Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl).

Authors:  Wei-Jie Fang; Thomas F Murray; Jane V Aldrich
Journal:  Bioorg Med Chem       Date:  2017-11-21       Impact factor: 3.641

4.  Structure-Activity Relationships of [des-Arg7]Dynorphin A Analogues at the κ Opioid Receptor.

Authors:  Cyf N Ramos-Colon; Yeon Sun Lee; Michael Remesic; Sara M Hall; Justin LaVigne; Peg Davis; Alexander J Sandweiss; Mary I McIntosh; Jessica Hanson; Tally M Largent-Milnes; Todd W Vanderah; John Streicher; Frank Porreca; Victor J Hruby
Journal:  J Med Chem       Date:  2016-11-08       Impact factor: 7.446

5.  Molecular dynamics simulations predict a tilted orientation for the helical region of dynorphin A(1-17) in dimyristoylphosphatidylcholine bilayers.

Authors:  R Sankararamakrishnan; H Weinstein
Journal:  Biophys J       Date:  2000-11       Impact factor: 4.033

6.  Alanine scan of the opioid peptide dynorphin B amide.

Authors:  Anand A Joshi; Thomas F Murray; Jane V Aldrich
Journal:  Biopolymers       Date:  2017-09       Impact factor: 2.505

7.  Local inhibitory effects of dynorphin A-(1-17) on capsaicin-induced thermal allodynia in rhesus monkeys.

Authors:  M C Ko; K J Willmont; A Burritt; V J Hruby; J H Woods
Journal:  Eur J Pharmacol       Date:  2000-08-18       Impact factor: 4.432

8.  Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women.

Authors:  A M Rometo; N E Rance
Journal:  J Neuroendocrinol       Date:  2008-12       Impact factor: 3.627

Review 9.  Peptide kappa opioid receptor ligands: potential for drug development.

Authors:  Jane V Aldrich; Jay P McLaughlin
Journal:  AAPS J       Date:  2009-05-09       Impact factor: 4.009

10.  Effect of three peptidase inhibitors on antinociceptive potential and toxicity with intracerebroventricular administration of dynorphin A (1-17) or (1-13) in the rat.

Authors:  Junko Ajimi; Masanobu Yoshikawa; Shigeru Takahashi; Masaaki Miura; Hideo Tsukamoto; Mitsuru Kawaguchi; Hiroyuki Kobayashi; Toshiyasu Suzuki
Journal:  J Anesth       Date:  2014-06-19       Impact factor: 2.078
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