Literature DB >> 9784571

Deletion of the major proteolytic site of the Helicobacter pylori cytotoxin does not influence toxin activity but favors assembly of the toxin into hexameric structures.

D Burroni1, P Lupetti, C Pagliaccia, J M Reyrat, R Dallai, R Rappuoli, J L Telford.   

Abstract

The Helicobacter pylori cytotoxin is proteolytically cleaved at a flexible hydrophilic loop into two subunits. Deletion of the loop sequences had no effect on biological activity of the toxin in the HeLa cell vacuolation assay but favored the organization of the protein into hexameric rather than heptameric structures.

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Year:  1998        PMID： 9784571      PMCID： PMC108697     

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  13 in total

1.  Chloramphenicol resistance in Campylobacter coli: nucleotide sequence, expression, and cloning vector construction.

Authors:  Y Wang; D E Taylor
Journal:  Gene       Date:  1990-09-28       Impact factor: 3.688

2.  Protease susceptibility and toxicity of heat-labile enterotoxins with a mutation in the active site or in the protease-sensitive loop.

Authors:  V Giannelli; M R Fontana; M M Giuliani; D Guangcai; R Rappuoli; M Pizza
Journal:  Infect Immun       Date:  1997-01       Impact factor: 3.441

3.  Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.

Authors:  P Lupetti; J E Heuser; R Manetti; P Massari; S Lanzavecchia; P L Bellon; R Dallai; R Rappuoli; J L Telford
Journal:  J Cell Biol       Date:  1996-05       Impact factor: 10.539

4.  Low pH activates the vacuolating toxin of Helicobacter pylori, which becomes acid and pepsin resistant.

Authors:  M de Bernard; E Papini; V de Filippis; E Gottardi; J Telford; R Manetti; A Fontana; R Rappuoli; C Montecucco
Journal:  J Biol Chem       Date:  1995-10-13       Impact factor: 5.157

5.  Helicobacter pylori cytotoxin: importance of native conformation for induction of neutralizing antibodies.

Authors:  R Manetti; P Massari; D Burroni; M de Bernard; A Marchini; R Olivieri; E Papini; C Montecucco; R Rappuoli; J L Telford
Journal:  Infect Immun       Date:  1995-11       Impact factor: 3.441

6.  Bafilomycin A1 inhibits Helicobacter pylori-induced vacuolization of HeLa cells.

Authors:  E Papini; M Bugnoli; M De Bernard; N Figura; R Rappuoli; C Montecucco
Journal:  Mol Microbiol       Date:  1993-01       Impact factor: 3.501

7.  Transformation of Helicobacter pylori by chromosomal metronidazole resistance and by a plasmid with a selectable chloramphenicol resistance marker.

Authors:  Y Wang; K P Roos; D E Taylor
Journal:  J Gen Microbiol       Date:  1993-10

8.  Gene disruption and replacement as a feasible approach for mutagenesis of Campylobacter jejuni.

Authors:  A Labigne-Roussel; P Courcoux; L Tompkins
Journal:  J Bacteriol       Date:  1988-04       Impact factor: 3.490

9.  Cytotoxic activity in broth-culture filtrates of Campylobacter pylori.

Authors:  R D Leunk; P T Johnson; B C David; W G Kraft; D R Morgan
Journal:  J Med Microbiol       Date:  1988-06       Impact factor: 2.472

10.  Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

Authors:  J L Telford; P Ghiara; M Dell'Orco; M Comanducci; D Burroni; M Bugnoli; M F Tecce; S Censini; A Covacci; Z Xiang
Journal:  J Exp Med       Date:  1994-05-01       Impact factor: 14.307
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  9 in total

1.  Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.

Authors:  X Ji; T Fernandez; D Burroni; C Pagliaccia; J C Atherton; J M Reyrat; R Rappuoli; J L Telford
Journal:  Infect Immun       Date:  2000-06       Impact factor: 3.441

2.  How the loop and middle regions influence the properties of Helicobacter pylori VacA channels.

Authors:  F Tombola; C Pagliaccia; S Campello; J L Telford; C Montecucco; E Papini; M Zoratti
Journal:  Biophys J       Date:  2001-12       Impact factor: 4.033

Review 3.  Type V protein secretion pathway: the autotransporter story.

Authors:  Ian R Henderson; Fernando Navarro-Garcia; Mickaël Desvaux; Rachel C Fernandez; Dlawer Ala'Aldeen
Journal:  Microbiol Mol Biol Rev       Date:  2004-12       Impact factor: 11.056

4.  A Helicobacter pylori Vacuolating Cytotoxin A: Mouse DHFR Fusion Protein Triggers Dye Release from Liposomes.

Authors:  Aung Khine Linn; Nitchakan Samainukul; Somsri Sakdee; Chanan Angsuthanasombat; Gerd Katzenmeier
Journal:  Curr Microbiol       Date:  2017-10-14       Impact factor: 2.188

5.  Deletion of Helicobacter pylori vacuolating cytotoxin gene by introduction of directed mutagenesis.

Authors:  Jian-Ping Yuan; Tao Li; Xiao-Dong Shi; Bao-Yu Hu; Gui-Zhen Yang; Shan-Qing Tong; Xiao-Kui Guo
Journal:  World J Gastroenterol       Date:  2003-10       Impact factor: 5.742

6.  Structural analysis of the oligomeric states of Helicobacter pylori VacA toxin.

Authors:  Melissa G Chambers; Tasia M Pyburn; Christian González-Rivera; Scott E Collier; Ilyas Eli; Calvin K Yip; Yoshimasa Takizawa; D Borden Lacy; Timothy L Cover; Melanie D Ohi
Journal:  J Mol Biol       Date:  2012-11-20       Impact factor: 5.469

Review 7.  Pleiotropic cytotoxicity of VacA toxin in host cells and its impact on immunotherapy.

Authors:  Farnaz Fahimi; Mohammad Reza Tohidkia; Mehdi Fouladi; Reza Aghabeygi; Naser Samadi; Yadollah Omidi
Journal:  Bioimpacts       Date:  2017-03-30

8.  New genotypes of Helicobacter Pylori VacA d-region identified from global strains.

Authors:  Djaleel Muhammad Soyfoo; Yussriya Hanaa Doomah; Dong Xu; Chao Zhang; Huai-Ming Sang; Yan-Yan Liu; Guo-Xin Zhang; Jian-Xia Jiang; Shun-Fu Xu
Journal:  BMC Mol Cell Biol       Date:  2021-01-07

Review 9.  Remodeling the host environment: modulation of the gastric epithelium by the Helicobacter pylori vacuolating toxin (VacA).

Authors:  Ik-Jung Kim; Steven R Blanke
Journal:  Front Cell Infect Microbiol       Date:  2012-03-27       Impact factor: 5.293
  9 in total

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