Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.

Literature DB >> 10816542

Cell specificity of Helicobacter pylori cytotoxin is determined by a short region in the polymorphic midregion.

X Ji¹, T Fernandez, D Burroni, C Pagliaccia, J C Atherton, J M Reyrat, R Rappuoli, J L Telford.

Abstract

There are two alleles of the vacuolating cytotoxin gene from Helicobacter pylori, which code for toxins with different cell specificities. By analyzing the phenotypes of natural and artificial chimeras between the two forms of the protein, we have delimited a short stretch of amino acids which determine the cell specificity.

Entities: Species

Mesh：

Substances：

Year: 2000 PMID： 10816542 PMCID： PMC97673 DOI： 10.1128/IAI.68.6.3754-3757.2000

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

15 in total

1. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity.

Authors: C Pagliaccia; M de Bernard; P Lupetti; X Ji; D Burroni; T L Cover; E Papini; R Rappuoli; J L Telford; J M Reyrat
Journal: Proc Natl Acad Sci U S A Date: 1998-08-18 Impact factor: 11.205

2. Three-dimensional reconstruction of metal replicas of the Helicobacter pylori vacuolating cytotoxin.

Authors: S Lanzavecchia; P L Bellon; P Lupetti; R Dallai; R Rappuoli; J L Telford
Journal: J Struct Biol Date: 1998-01 Impact factor: 2.867

3. Binding and internalization of the Helicobacter pylori vacuolating cytotoxin by epithelial cells.

Authors: J A Garner; T L Cover
Journal: Infect Immun Date: 1996-10 Impact factor: 3.441

4. Simple and accurate PCR-based system for typing vacuolating cytotoxin alleles of Helicobacter pylori.

Authors: J C Atherton; T L Cover; R J Twells; M R Morales; C J Hawkey; M J Blaser
Journal: J Clin Microbiol Date: 1999-09 Impact factor: 5.948

Review 5. Towards deciphering the Helicobacter pylori cytotoxin.

Authors: J M Reyrat; V Pelicic; E Papini; C Montecucco; R Rappuoli; J L Telford
Journal: Mol Microbiol Date: 1999-10 Impact factor: 3.501

6. Failure to confirm association of vac A gene mosaicism with duodenal ulcer disease.

Authors: M F Go; L Cissell; D Y Graham
Journal: Scand J Gastroenterol Date: 1998-02 Impact factor: 2.423

7. Oligomeric and subunit structure of the Helicobacter pylori vacuolating cytotoxin.

Authors: P Lupetti; J E Heuser; R Manetti; P Massari; S Lanzavecchia; P L Bellon; R Dallai; R Rappuoli; J L Telford
Journal: J Cell Biol Date: 1996-05 Impact factor: 10.539

8. Prevalence of vacuolating cytotoxin production and distribution of distinct vacA alleles in Helicobacter pylori from China.

Authors: Z J Pan; D E Berg; R W van der Hulst; W W Su; A Raudonikiene; S D Xiao; J Dankert; G N Tytgat; A van der Ende
Journal: J Infect Dis Date: 1998-07 Impact factor: 5.226

9. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration.

Authors: J C Atherton; P Cao; R M Peek; M K Tummuru; M J Blaser; T L Cover
Journal: J Biol Chem Date: 1995-07-28 Impact factor: 5.157

10. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease.

Authors: J L Telford; P Ghiara; M Dell'Orco; M Comanducci; D Burroni; M Bugnoli; M F Tecce; S Censini; A Covacci; Z Xiang
Journal: J Exp Med Date: 1994-05-01 Impact factor: 14.307

37 in total

1. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels.

Authors: F Tombola; C Pagliaccia; S Campello; J L Telford; C Montecucco; E Papini; M Zoratti
Journal: Biophys J Date: 2001-12 Impact factor: 4.033

2. Association of nonsynonymous substitutions in the intermediate region of the vacA gene of Helicobacter pylori with gastric diseases in Taiwan.

Authors: Shew-Meei Sheu; Kuei-Hsiang Hung; Bor-Shyang Sheu; Hsiao-Bai Yang; Jiunn-Jong Wu
Journal: J Clin Microbiol Date: 2008-11-19 Impact factor: 5.948

3. The cell-specific phenotype of the polymorphic vacA midregion is independent of the appearance of the cell surface receptor protein tyrosine phosphatase beta.

Authors: David A G Skibinski; Christophe Genisset; Silvia Barone; John L Telford
Journal: Infect Immun Date: 2006-01 Impact factor: 3.441

Review 4. Role of Helicobacter pylori infection in pathogenesis of gastric carcinoma.

Authors: Rong-Guang Zhang; Guang-Cai Duan; Qing-Tang Fan; Shuai-Yin Chen
Journal: World J Gastrointest Pathophysiol Date: 2016-02-15

5. Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study.

Authors: Ameer A Memon; Nawfal R Hussein; Véronique Y Miendje Deyi; Alain Burette; John C Atherton
Journal: J Clin Microbiol Date: 2014-06-11 Impact factor: 5.948