Literature DB >> 9784490

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

H Min1, D M Danilenko, S A Scully, B Bolon, B D Ring, J E Tarpley, M DeRose, W S Simonet.   

Abstract

Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10(-/-) mice. Strikingly, Fgf-10(-/-) fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for apical ectodermal ridge (AER) formation and acts epistatically upstream of Fgf-8, the earliest known AER marker in mice. Fgf-10(-/-) mice exhibited perinatal lethality associated with complete absence of lungs. Although tracheal development was normal, main-stem bronchial formation, as well as all subsequent pulmonary branching morphogenesis, was completely disrupted. The pulmonary phenotype of Fgf-10(-/-) mice is strikingly similar to that of the Drosophila mutant branchless, an Fgf homolog.

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Year:  1998        PMID： 9784490      PMCID： PMC317210          DOI： 10.1101/gad.12.20.3156

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  37 in total

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  267 in total

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9.  Branching morphogenesis.

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10.  Therapeutic effects of fibroblast growth factor-10 on hyperoxia-induced bronchopulmonary dysplasia in neonatal mice.

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