Literature DB >> 9784137

Attenuation of virulence by disruption of the Mycobacterium tuberculosis erp gene.

F X Berthet1, M Lagranderie, P Gounon, C Laurent-Winter, D Ensergueix, P Chavarot, F Thouron, E Maranghi, V Pelicic, D Portnoï, G Marchal, B Gicquel.   

Abstract

The virulence of the mycobacteria that cause tuberculosis depends on their ability to multiply in mammalian hosts. Disruption of the bacterial erp gene, which encodes the exported repetitive protein, impaired multiplication of M. tuberculosis and M. bovis Bacille Calmette-Guérin in cultured macrophages and mice. Reintroduction of erp into the mutants restored their ability to multiply. These results indicate that erp contributes to the virulence of M. tuberculosis.

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Year:  1998        PMID： 9784137     DOI： 10.1126/science.282.5389.759

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  52 in total

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2.  Plasmidic versus insertional cloning of heterologous genes in Mycobacterium bovis BCG: impact on in vivo antigen persistence and immune responses.

Authors:  I Méderlé; I Bourguin; D Ensergueix; E Badell; J Moniz-Peireira; B Gicquel; N Winter
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Review 6.  Insights into early mycobacterial pathogenesis from the zebrafish.

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Review 8.  Virulence factors of the Mycobacterium tuberculosis complex.

Authors:  Marina A Forrellad; Laura I Klepp; Andrea Gioffré; Julia Sabio y García; Hector R Morbidoni; María de la Paz Santangelo; Angel A Cataldi; Fabiana Bigi
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9.  Two nonredundant SecA homologues function in mycobacteria.

Authors:  M Braunstein; A M Brown; S Kurtz; W R Jacobs
Journal:  J Bacteriol       Date:  2001-12       Impact factor: 3.490

10.  Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial virulence loci.

Authors:  Christine L Cosma; Olivier Humbert; David R Sherman; Lalita Ramakrishnan
Journal:  J Infect Dis       Date:  2008-12-15       Impact factor: 5.226
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