BACKGROUND: S-100, a protein of astroglial cells, is described as a marker for central nervous system damage. The aim of this study was to evaluate whether the marker could give information about the severity and possibility of functional recovery after minor and severe head injury. METHODS: Thirty patients after severe head injury (Glasgow Coma Scale score < 9) and 11 patients after minor head injury (Glasgow Coma Scale score > 12) were included. In each case, blood samples were drawn within 6 hours after injury. Outcome was estimated at hospital discharge using the Glasgow Outcome Scale. RESULTS: All patients who sustained minor head injury had reached a favorable outcome by the time they were discharged from the hospital. Their mean S-100 serum level was 0.35 microg/L. Patients who sustained severe head injury and were classified as having an unfavorable outcome (31%) showed a mean serum concentration of 4.9 microg/L, whereas patients classified as having a favorable outcome (69%) had a mean S-100 level of 1.2 microg/L. All groups differed significantly (p < 0.05). CONCLUSION: S-100 appears to be a promising marker for the severity of head injury and neuronal damage.
BACKGROUND:S-100, a protein of astroglial cells, is described as a marker for central nervous system damage. The aim of this study was to evaluate whether the marker could give information about the severity and possibility of functional recovery after minor and severe head injury. METHODS: Thirty patients after severe head injury (Glasgow Coma Scale score < 9) and 11 patients after minor head injury (Glasgow Coma Scale score > 12) were included. In each case, blood samples were drawn within 6 hours after injury. Outcome was estimated at hospital discharge using the Glasgow Outcome Scale. RESULTS: All patients who sustained minor head injury had reached a favorable outcome by the time they were discharged from the hospital. Their mean S-100 serum level was 0.35 microg/L. Patients who sustained severe head injury and were classified as having an unfavorable outcome (31%) showed a mean serum concentration of 4.9 microg/L, whereas patients classified as having a favorable outcome (69%) had a mean S-100 level of 1.2 microg/L. All groups differed significantly (p < 0.05). CONCLUSION:S-100 appears to be a promising marker for the severity of head injury and neuronal damage.
Authors: Stefania Mondello; Uwe Muller; Andreas Jeromin; Jackson Streeter; Ronald L Hayes; Kevin K W Wang Journal: Expert Rev Mol Diagn Date: 2011-01 Impact factor: 5.225
Authors: J R De Kruijk; P Leffers; P P C A Menheere; S Meerhoff; J Rutten; A Twijnstra Journal: J Neurol Neurosurg Psychiatry Date: 2002-12 Impact factor: 10.154
Authors: Linda Papa; Salvatore Silvestri; Gretchen M Brophy; Philip Giordano; Jay L Falk; Carolina F Braga; Ciara N Tan; Neema J Ameli; Jason A Demery; Neha K Dixit; Matthew E Mendes; Ronald L Hayes; Kevin K W Wang; Claudia S Robertson Journal: J Neurotrauma Date: 2014-09-12 Impact factor: 5.269
Authors: P Biberthaler; T Mussack; K-G Kanz; U Linsenmaier; K-J Pfeifer; W Mutschler; M Jochum Journal: Unfallchirurg Date: 2004-03 Impact factor: 1.000
Authors: Anil Rajendra; Philip C Spinella; Henry R Drott; Troy E Dominguez; Leslie Sutton; Mark Helfaer Journal: J Neurooncol Date: 2004-05 Impact factor: 4.130
Authors: John E Buonora; Angela M Yarnell; Rachel C Lazarus; Michael Mousseau; Lawrence L Latour; Sandro B Rizoli; Andrew J Baker; Shawn G Rhind; Ramon Diaz-Arrastia; Gregory P Mueller Journal: Front Neurol Date: 2015-03-30 Impact factor: 4.003