| Literature DB >> 978135 |
Abstract
Structural variation in the second component of human complement was identified in about 4% of serum samples from random unrelated individuals of all the major races. Three forms of C2 have been identified by isoelectric focusing in polyacrylamide gel and development of patterns in agarose gel containing antibody-sensitized sheep red cells and C2-deficient serum: C2 C (common), C2 A (acidic), and C2 B (basic). The C2 variants were shown to be inherited as autosomal codominant traits, and suggestive evidence for close linkage between C2 and Bf was obtained.Entities:
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Year: 1976 PMID： 978135 PMCID： PMC2190428 DOI： 10.1084/jem.144.4.1111
Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307