Literature DB >> 4176438

Genetic polymorphism of C'3(beta1C-globulin) in human serum.

E A Azen, O Smithies.   

Abstract

Genetic polymorphism of the third component of human complement and its breakdown products has been detected in human serum by high-voltage starch-gel electrophoresis. Six phenotypes were observed in a study of 113 randomly chosen Caucasians. Their inheritance is controlled by four codominant alleles at an autosomal locus. The gene frequencies in this study were C3(1), 0.21; C3(2), 0.77; C3(3), approximately 0.01; and C3(4), approximately 0.004.

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Year:  1968        PMID： 4176438     DOI： 10.1126/science.162.3856.905

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

1.  Genetic polymorphism of serum complement components in the chimpanzee.

Authors:  D Raum; H Balner; B H Petersen; C A Alper
Journal:  Immunogenetics       Date:  1980       Impact factor: 2.846

2.  Distribution of complement C3 variants in individuals with cystic fibrosis.

Authors:  S Lederberg; D Sackett
Journal:  Am J Hum Genet       Date:  1976-11       Impact factor: 11.025

Review 3.  Complement genetics, deficiencies, and disease associations.

Authors:  Karine R Mayilyan
Journal:  Protein Cell       Date:  2012-07-10       Impact factor: 14.870

4.  Genetic polymorphism of C3 and serum levels of immunoglobulins, C3, C4 components of complement and C3-proactivator in four different populations of Afghanistan.

Authors:  D P Agarwal; H W Goedde; H G Benkmann; G Flatz; A G Rahimi; S Kaifie; H Delbrúck
Journal:  Hum Genet       Date:  1976-07-07       Impact factor: 4.132

5.  [Use of C3(beta-1c-globulin)-polymorphism in cases of disputed paternity (author's transl)].

Authors:  D D Farhud; H Walter
Journal:  Z Rechtsmed       Date:  1973-05-24

6.  Polymorphism of C'3 in German, Bulgarian, Iranian and Angola population.

Authors:  D D Farhud; H Walter
Journal:  Humangenetik       Date:  1973

7.  [Studies on C'3-polymorphism ( 1c -globulin). Gene frequencies and family studies in blood donors from Hessen and a Bantu population].

Authors:  P Kühnl; W Spielmann
Journal:  Humangenetik       Date:  1972

8.  [On typing the C3-system: Inhibition of the conversion by EDTA-Na2 (chelaplex III) (author's transl)].

Authors:  D Patzelt; G Geserick; E Lignitz
Journal:  Z Rechtsmed       Date:  1977-08-26

9.  Results on forensic application of the C3 system.

Authors:  G Geserick; O Prokop; H Waltz
Journal:  Z Rechtsmed       Date:  1980

10.  Allele frequencies of the third component of complement (C3) in MS patients.

Authors:  D E Bulman; H Armstrong; G C Ebers
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-06       Impact factor: 10.154
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