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Literature DB >> 9781041

A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9.

S M Leal¹, F Apaydin, C Barnwell, M Iber, T Kandogan, M Pfister, U Braendle, O Cura, M Schwalb, H P Zenner, E Vitale.

Abstract

A second kindred has been identified which supports the previously reported location of DFNB9. Linkage has been established to markers closely linked to DFNB9 which is located on 2p22-p23. The hearing impaired individuals in this highly consanguineous kindred from Eastern Turkey have prelingual profound hearing loss which affects all frequencies. A genetic map of the 2p22-p23 region where DFNB9 resides was generated using marker genotypes available from the CEPH database. All markers were placed on this genetic map using a likelihood ratio criterion of 1000:1. This map suggests that the region for DFNB9 is less than 1.08 cM, 95% confidence interval (0-2.59 cM).

Entities: Disease Species

Mesh：

Year: 1998 PMID： 9781041 PMCID： PMC6141006 DOI： 10.1038/sj.ejhg.5200201

Source DB: PubMed Journal: Eur J Hum Genet ISSN： 1018-4813 Impact factor: 4.246

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References

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A second middle eastern kindred with autosomal recessive non-syndromic hearing loss segregates DFNB9.

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