Literature DB >> 9771957

Phase II trial of titanocene dichloride in advanced renal-cell carcinoma.

G Lümmen1, H Sperling, H Luboldt, T Otto, H Rübben.   

Abstract

Titanocene dichloride was capable of inhibiting the growth of different types of human tumors in vitro. A total of 14 patients with metastatic renal-cell carcinoma (RCC) received 270 mg/m2 titanocene dichloride every 3 weeks for 6 weeks. Although the toxicities and side effects encountered were mild to moderate, no partial or complete response was detectable. In conclusion, titanocene dichloride has no advantage in the therapy of RCC.

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Year:  1998        PMID： 9771957     DOI： 10.1007/s002800050838

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  36 in total

1.  Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA.

Authors:  Jose F González-Pantoja; Michael Stern; Andrzej A Jarzecki; Eva Royo; Elisa Robles-Escajeda; Armando Varela-Ramírez; Renato J Aguilera; María Contel
Journal:  Inorg Chem       Date:  2011-09-29       Impact factor: 5.165

2.  Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.

Authors:  Li Ming Gao; Jaime Matta; Arnold L Rheingold; Enrique Meléndez
Journal:  J Organomet Chem       Date:  2009-12-15       Impact factor: 2.369

3.  Synthesis and cytotoxicity studies of steroid-functionalized titanocenes as potential anticancer drugs: sex steroids as potential vectors for titanocenes.

Authors:  Li Ming Gao; José L Vera; Jaime Matta; Enrique Meléndez
Journal:  J Biol Inorg Chem       Date:  2010-03-28       Impact factor: 3.358

4.  Specific Interactions of Antitumor Metallocenes with Deoxydinucleoside Monophosphates.

Authors:  Rahel P Eberle; Yvonne Hari; Stefan Schürch
Journal:  J Am Soc Mass Spectrom       Date:  2017-05-12       Impact factor: 3.109

5.  Regulation of the aggregation behavior of human islet amyloid polypeptide fragment by titanocene complexes.

Authors:  Weihong Du; Gehui Gong; Wenji Wang; Jufei Xu
Journal:  J Biol Inorg Chem       Date:  2017-08-11       Impact factor: 3.358

6.  Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways.

Authors:  Kogularamanan Suntharalingam; Timothy C Johnstone; Peter M Bruno; Wei Lin; Michael T Hemann; Stephen J Lippard
Journal:  J Am Chem Soc       Date:  2013-09-16       Impact factor: 15.419

7.  Titanium(IV) complexes: cytotoxicity and cellular uptake of titanium(IV) complexes on caco-2 cell line.

Authors:  Ramón Hernández; Janet Méndez; José Lamboy; Madeline Torres; Féliz R Román; Enrique Meléndez
Journal:  Toxicol In Vitro       Date:  2009-09-20       Impact factor: 3.500

8.  In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(eta-cyclopentadienyl)difluorotitanium(IV).

Authors:  Elias Koleros; Theocharis C Stamatatos; Vassilis Psycharis; Catherine P Raptopoulou; Spyros P Perlepes; Nikolaos Klouras
Journal:  Bioinorg Chem Appl       Date:  2010-06-23       Impact factor: 7.778

9.  New tungstenocenes containing 3-hydroxy-4-pyrone ligands: antiproliferative activity on HT-29 and MCF-7 cell lines and binding to human serum albumin studied by fluorescence spectroscopy and molecular modeling methods.

Authors:  Moralba Domínguez-García; Carlos Ortega-Zúñiga; Enrique Meléndez
Journal:  J Biol Inorg Chem       Date:  2012-12-05       Impact factor: 3.358

10.  A proposed mechanism for the inhibitory effect of the anticancer agent titanocene dichloride on tumour gelatinases and other proteolytic enzymes.

Authors:  Maria Pavlaki; Katerina Debeli; Irene-Eva Triantaphyllidou; Nikolaos Klouras; Eleftheria Giannopoulou; Alexios J Aletras
Journal:  J Biol Inorg Chem       Date:  2009-04-24       Impact factor: 3.358
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