Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
Nine amide-functionalized n class="Chemical">titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
Authors: C V Christodoulou; D R Ferry; D W Fyfe; A Young; J Doran; T M Sheehan; A Eliopoulos; K Hale; J Baumgart; G Sass; D J Kerr Journal: J Clin Oncol Date: 1998-08 Impact factor: 44.544
Authors: Sergio A Loza-Rosas; Alexandra M Vázquez-Salgado; Kennett I Rivero; Lenny J Negrón; Yamixa Delgado; Josué A Benjamín-Rivera; Angel L Vázquez-Maldonado; Timothy B Parks; Charlene Munet-Colón; Arthur D Tinoco Journal: Inorg Chem Date: 2017-06-23 Impact factor: 5.165