OBJECTIVE: A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. METHODS: Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene. RESULTS: The IGF-1 locus was significantly associated with the presence of ROA (over-all adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). CONCLUSION: These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.
OBJECTIVE: A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene. METHODS: Subjects aged 55-65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene. RESULTS: The IGF-1 locus was significantly associated with the presence of ROA (over-all adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2). CONCLUSION: These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.
Authors: G Zhai; F Rivadeneira; J J Houwing-Duistermaat; I Meulenbelt; C Bijkerk; A Hofman; J B J van Meurs; A G Uitterlinden; H A P Pols; P E Slagboom; C M van Duijn Journal: Ann Rheum Dis Date: 2004-05 Impact factor: 19.103
Authors: Bonny L Specker; Howard E Wey; Teresa L Binkley; Tianna M Beare; Eric P Smith; Frank Rauch Journal: Bone Date: 2010-01-04 Impact factor: 4.398
Authors: Huiyong Zheng; Maryfran Sowers; Carrie Karvonen-Gutierrez; Jon A Jacobson; John F Randolph; Siobàn D Harlow Journal: J Syst Cybern Inf Date: 2012
Authors: H Bukulmez; A L Matthews; C M Sullivan; C Chen; M J Kraay; R C Elston; R W Moskowitz; V M Goldberg; M L Warman Journal: Arthritis Res Ther Date: 2006-01-03 Impact factor: 5.156