OBJECTIVE: Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved. This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population. METHODS: The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjects who were diagnosed as knee osteoarthritis and in 179 healthy controls. RESULTS: Rs1871054 was found to be significantly associated with increased risk of OA (C vs. T, OR 1.802 (1.308 to 2.483), P < 0.0001) after adjustment of age, gender, and BMI. For other SNPs, no statistically significant associations with OA were found. CONCLUSION: In conclusion, our data demonstrated the ADAM12 rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.
OBJECTIVE: Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved. This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population. METHODS: The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjects who were diagnosed as knee osteoarthritis and in 179 healthy controls. RESULTS:Rs1871054 was found to be significantly associated with increased risk of OA (C vs. T, OR 1.802 (1.308 to 2.483), P < 0.0001) after adjustment of age, gender, and BMI. For other SNPs, no statistically significant associations with OA were found. CONCLUSION: In conclusion, our data demonstrated the ADAM12rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.
Authors: Irina Kerna; Kalle Kisand; Siim Suutre; Maret Murde; Ann Tamm; Jaanika Kumm; Agu Tamm Journal: Joint Bone Spine Date: 2013-04-09 Impact factor: 4.929
Authors: Ana M Valdes; John Loughlin; Mark Van Oene; Kay Chapman; Gabriela L Surdulescu; Michael Doherty; Tim D Spector Journal: Arthritis Rheum Date: 2007-01
Authors: E Pola; P Papaleo; R Pola; E Gaetani; F C Tamburelli; L Aulisa; C A Logroscino Journal: Osteoarthritis Cartilage Date: 2005-09-29 Impact factor: 6.576
Authors: Ana M Valdes; Mark Van Oene; Deborah J Hart; Gabriela L Surdulescu; John Loughlin; Michael Doherty; Tim D Spector Journal: Arthritis Rheum Date: 2006-02
Authors: J Rodriguez-Lopez; M Pombo-Suarez; J Loughlin; A Tsezou; F J Blanco; I Meulenbelt; P E Slagboom; A M Valdes; T D Spector; J J Gomez-Reino; A Gonzalez Journal: Osteoarthritis Cartilage Date: 2008-09-14 Impact factor: 6.576
Authors: Ana M Valdes; Deborah J Hart; Karen A Jones; Gabriela Surdulescu; Peter Swarbrick; David V Doyle; Alan J Schafer; Tim D Spector Journal: Arthritis Rheum Date: 2004-08
Authors: Kholoud Hafsi; Janine McKay; Jinjie Li; José Fábio Lana; Alex Macedo; Gabriel Silva Santos; William D Murrell Journal: J Clin Orthop Trauma Date: 2018-10-15