Literature DB >> 9765578

Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa.

K Evans1, L Passador, R Srikumar, E Tsang, J Nezezon, K Poole.   

Abstract

Pseudomonas aeruginosa nalB mutants which hyperexpress the MexAB-OprM multidrug efflux system produce reduced levels of several extracellular virulence factors known to be regulated by quorum sensing. Such mutants also produce less acylated homoserine lactone autoinducer PAI-1, consistent with an observed reduction in lasI expression. These data suggest that PAI-1 is a substrate for MexAB-OprM, and its resulting exclusion from cells hyperexpressing MexAB-OprM limits PAI-1-dependent activation of lasI and the virulence genes.

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Year:  1998        PMID： 9765578      PMCID： PMC107595     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  37 in total

1.  Efflux pumps and drug resistance in gram-negative bacteria.

Authors:  D Ma; D N Cook; J E Hearst; H Nikaido
Journal:  Trends Microbiol       Date:  1994-12       Impact factor: 17.079

2.  Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum.

Authors:  A Schäfer; A Tauch; W Jäger; J Kalinowski; G Thierbach; A Pühler
Journal:  Gene       Date:  1994-07-22       Impact factor: 3.688

3.  Beta-lactamase inhibitors are substrates for the multidrug efflux pumps of Pseudomonas aeruginosa.

Authors:  X Z Li; L Zhang; R Srikumar; K Poole
Journal:  Antimicrob Agents Chemother       Date:  1998-02       Impact factor: 5.191

4.  A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.

Authors:  J P Pearson; L Passador; B H Iglewski; E P Greenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

5.  Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.

Authors:  K E Hagman; W Pan; B G Spratt; J T Balthazar; R C Judd; W M Shafer
Journal:  Microbiology       Date:  1995-03       Impact factor: 2.777

6.  Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family.

Authors:  J M Brint; D E Ohman
Journal:  J Bacteriol       Date:  1995-12       Impact factor: 3.490

7.  Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa.

Authors:  X Z Li; H Nikaido; K Poole
Journal:  Antimicrob Agents Chemother       Date:  1995-09       Impact factor: 5.191

8.  Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa.

Authors:  U A Ochsner; J Reiser
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

9.  Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.

Authors:  D Ma; D N Cook; M Alberti; N G Pon; H Nikaido; J E Hearst
Journal:  Mol Microbiol       Date:  1995-04       Impact factor: 3.501

10.  Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1.

Authors:  A Latifi; M K Winson; M Foglino; B W Bycroft; G S Stewart; A Lazdunski; P Williams
Journal:  Mol Microbiol       Date:  1995-07       Impact factor: 3.501
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  92 in total

1.  Insertion mutagenesis and membrane topology model of the Pseudomonas aeruginosa outer membrane protein OprM.

Authors:  K K Wong; R E Hancock
Journal:  J Bacteriol       Date:  2000-05       Impact factor: 3.490

Review 2.  Molecular properties of bacterial multidrug transporters.

Authors:  M Putman; H W van Veen; W N Konings
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

3.  Brucella melitensis: a nasty bug with hidden credentials for virulence.

Authors:  Edgardo Moreno; Ignacio Moriyon
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-08       Impact factor: 11.205

Review 4.  Mob psychology.

Authors:  Stephen C Winans; Bonnie L Bassler
Journal:  J Bacteriol       Date:  2002-02       Impact factor: 3.490

5.  Early activation of quorum sensing.

Authors:  James P Pearson
Journal:  J Bacteriol       Date:  2002-05       Impact factor: 3.490

Review 6.  Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria.

Authors:  K Poole
Journal:  Antimicrob Agents Chemother       Date:  2000-09       Impact factor: 5.191

7.  Multidrug efflux pumps: expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms.

Authors:  T R De Kievit; M D Parkins; R J Gillis; R Srikumar; H Ceri; K Poole; B H Iglewski; D G Storey
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 8.  Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance.

Authors:  José L Martínez; Fernando Baquero
Journal:  Clin Microbiol Rev       Date:  2002-10       Impact factor: 26.132

9.  HNP-3 enhanced the antimicrobial activity of CIP by promoting ATP efflux from P. aeruginosa cells.

Authors:  Hao Wang; Birong Dong; Li Lou
Journal:  Mol Biol Rep       Date:  2010-11-25       Impact factor: 2.316

10.  Metabolic compensation of fitness costs associated with overexpression of the multidrug efflux pump MexEF-OprN in Pseudomonas aeruginosa.

Authors:  Jorge Olivares; Carolina Álvarez-Ortega; José Luis Martinez
Journal:  Antimicrob Agents Chemother       Date:  2014-04-28       Impact factor: 5.191
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