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Literature DB >> 976307

Pharmacokinetics of amitriptyline infused intravenously in man.

Abstract

Amitriptyline was given to four male volunteers by constant rate intravenous infusion. Blood samples were collected before, during and at various times after the infusion for estimation of the serum concentrations of amitriptyline. The level of nortriptyline never reached a detectable level. A two compartment open model was shown to be applicable to the data obtained. The meaning of the parameters obtained by a non-linear, least squares curve fitting procedure is discussed and the values are compared to those recently published for nortriptyline. The calculated biological half-life of amitriptyline was about 17 hours, a figure which differs considerably from previously calculated values for volunteers, but is in accordance with some newer results from patients.

Entities: Chemical Species

Mesh：

Substances：
Amitriptyline

Year: 1976 PMID： 976307 DOI： 10.1007/BF00565623

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

10 in total

1. On the biological half-life of amitroptyline.

Authors: A Jøorgensen; P Staehr
Journal: J Pharm Pharmacol Date: 1976-01 Impact factor: 3.765

2. A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum.

Authors: A Jorgensen
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1975-01

3. First-pass metabolism of nortriptyline in man.

Authors: L F Gram; K F Overo
Journal: Clin Pharmacol Ther Date: 1975-09 Impact factor: 6.875

4. Application of isotope derivative technique to assay of secondary amines: estimation of desipramine by acetylation with H3-acetic anhydride.

Authors: W M Hammer; B B Brodiet
Journal: J Pharmacol Exp Ther Date: 1967-09 Impact factor: 4.030

5. Plasma concentration of amitriptyline and clinical response.

Authors: R A Braithwaite; R Goulding; G Theano; J Bailey; A Coppen
Journal: Lancet Date: 1972-06-17 Impact factor: 79.321

6. Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.

Authors: B Alexanderson
Journal: Eur J Clin Pharmacol Date: 1972-03 Impact factor: 2.953

7. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.

Authors: L Z Benet
Journal: J Pharm Sci Date: 1972-04 Impact factor: 3.534

8. Integral coefficients of multi-compartment pharmacokinetic models. Application to chemotherapy.

Authors: W J Jusko; G P Lewis; L W Dittert
Journal: Chemotherapy Date: 1972 Impact factor: 2.544

9. A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients.

Authors: R A Braithwaite; B Widdop
Journal: Clin Chim Acta Date: 1971-12 Impact factor: 3.786

9. Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

Authors: P Baumann; J M Gaillard; M Jonzier-Perey; C Gerber; C Bouras
Journal: Psychopharmacology (Berl) Date: 1984 Impact factor: 4.530

10. Pharmacokinetic studies in volunteers of intravenous and oral cis (Z)-flupentixol and intramuscular cis (Z)-flupentixol decanoate in Viscoleo.

Authors: A Jørgensen
Journal: Eur J Clin Pharmacol Date: 1980-10 Impact factor: 2.953

10 in total

Pharmacokinetics of amitriptyline infused intravenously in man.

1. On the biological half-life of amitroptyline.

2. A gas chromatographic method for the determination of amitriptyline and nortriptyline in human serum.

3. First-pass metabolism of nortriptyline in man.

4. Application of isotope derivative technique to assay of secondary amines: estimation of desipramine by acetylation with H3-acetic anhydride.

5. Plasma concentration of amitriptyline and clinical response.

6. Pharmacokinetics of nortriptyline in man after single and multiple oral doses: the predictability of steady-state plasma concentrations from single-dose plasma-level data.

7. General treatment of linear mammillary models with elimination from any compartment as used in pharmacokinetics.

8. Integral coefficients of multi-compartment pharmacokinetic models. Application to chemotherapy.

9. A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients.

10. Kinetics of nortriptyline in man according to a two compartment model.

Review 1. Pharmacokinetics of haemoperfusion for drug overdose.

Review 2. Plasma level monitoring of tricyclic antidepressant therapy.

Review 3. Discrepancies between pharmacokinetic studies of amitriptyline.

4. Predicative calculation of the efficiency of hemodialysis or hemoperfusion for the removal of drugs from the body.

5. Comparative bioavailability of a sustained release preparation of amitriptyline and conventional tablets.

6. The half-life of amitriptyline.

7. Pharmacokinetic characterization of extracorporeal therapy.

8. Amitriptyline pharmacokinetics. A crossover study with single doses of amitriptyline and nortriptyline.

9. Evaluation of the levels of free and total amitriptyline and metabolites in the plasma and brain of the rat after long-term administration of doses used in receptor studies.

10. Pharmacokinetic studies in volunteers of intravenous and oral cis (Z)-flupentixol and intramuscular cis (Z)-flupentixol decanoate in Viscoleo.