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Literature DB >> 3977598

Predicative calculation of the efficiency of hemodialysis or hemoperfusion for the removal of drugs from the body.

Abstract

Formula are derived for the calculation of the amounts of drug which, during a defined time interval, are eliminated from the body with and without the help of hemodialysis or hemoperfusion (HD/HP). A programmable pocket calculator like the TI-59 suffices to perform all calculations. The pharmacokinetic system constants of the drug, the effective plasma flow, and the HD/HP plasma extraction rate are entered into the program. Additional information can be obtained if the plasma concentration of the drug at the onset of HD/HP is known. Worked examples are presented.

Entities: Disease

Mesh：

Substances：

Year: 1985 PMID： 3977598 DOI： 10.1007/bf00333424

Source DB: PubMed Journal: Arch Toxicol ISSN： 0340-5761 Impact factor: 5.153

18 in total

1. Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients.

Authors: M Linnoila; F Dorrity; K Jobson
Journal: Am J Psychiatry Date: 1978-05 Impact factor: 18.112

2. Kinetic modeling of hemodialysis, hemofiltration, and hemodiafiltration.

Authors: K B Sprenger; W Kratz; A E Lewis; U Stadtmüller
Journal: Kidney Int Date: 1983-08 Impact factor: 10.612

3. Blood/plasma distribution ratios of psychotropic drugs.

Authors: K P Maguire; G D Burrows; T R Norman; B A Scoggins
Journal: Clin Chem Date: 1980-10 Impact factor: 8.327

4. Plasma protein binding and distribution characteristics of drugs as indices of their hemodialyzability.

Authors: P R Gwilt; D Perrier
Journal: Clin Pharmacol Ther Date: 1978-08 Impact factor: 6.875

5. Patient-hemodialyzer interactions.

Authors: K Schindhelm; P C Farrell
Journal: Trans Am Soc Artif Intern Organs Date: 1978

6. Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker.

Authors: H C Brown; S G Carruthers; G D Johnston; J G Kelly; J McAinsh; D G McDevitt; R G Shanks
Journal: Clin Pharmacol Ther Date: 1976-11 Impact factor: 6.875

7. Clearance and recovery calculations in hemodialysis: application to plasma, red blood cells, and dialysate measurements for cyclophosphamide.

Authors: L H Wang; C S Lee; B L Majeske; T C Marbury
Journal: Clin Pharmacol Ther Date: 1981-03 Impact factor: 6.875

Predicative calculation of the efficiency of hemodialysis or hemoperfusion for the removal of drugs from the body.

1. Plasma and erythrocyte levels of tricyclic antidepressants in depressed patients.

2. Kinetic modeling of hemodialysis, hemofiltration, and hemodiafiltration.

3. Blood/plasma distribution ratios of psychotropic drugs.

4. Plasma protein binding and distribution characteristics of drugs as indices of their hemodialyzability.

5. Patient-hemodialyzer interactions.

6. Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker.

7. Clearance and recovery calculations in hemodialysis: application to plasma, red blood cells, and dialysate measurements for cyclophosphamide.

8. Pharmacokinetics of amitriptyline infused intravenously in man.

9. Pharmacokinetics of atenolol in patients with terminal renal failure and influence of haemodialysis.

Review 10. Drug therapy in patients undergoing haemodialysis. Clinical pharmacokinetic considerations.

Review 1. Clinical pharmacokinetics of ethanol.

2. Toxicokinetics of labeled amatoxins in the dog.